病证结合便秘动物模型研究进展

Animal Constipation Models Combining the Disease and Syndrome:A Review

中医治疗便秘相比西药具有远期疗效好、不良反应小等优势,但治疗机制的研究却并不完善。研究中医药治疗便秘的具体机制,应参照中医理论建立科学合理的中医证型动物模型。现有研究多以“病-证结合”的方法复制中医证型动物模型,通过文献总结发现存在用药剂量、造模时间、造模流程叙述不清,甚至模型运用不合理的问题。为归纳探索中医证型便秘模型的造模方法,通过文献综述的方式,归纳阐述脾虚型便秘、血虚型便秘、阳虚型便秘、津亏型便秘的现有造模方法,造模流程以及评价标准。

Traditional Chinese medicine(TCM)has long-lasting efficacy and low potentiality in inducing adverse reactions in the treatment of constipation compared with western medicine.However,no systemic research on the mechanism is available,and a science-based animal model with the corresponding syndrome is the premise for the exploring the anti-constipation mechanism.Currently available Animal models of TCM syndromes are mainly established with the method of“combining disease and syndrome”.Through literature research,it is found that there are problems such as unclear description of drug dosage,modeling time,and modeling process,and even unreasonable application of the model.In order to summarize and explore the modeling methods of constipation with TCM syndrome,this study summarized the existing modeling methods,modeling process,and model evaluation criteria of constipation with spleen deficiency type,blood deficiency type,yang deficiency type,and fluid deficiency type through literature research.