高压氧辅助治疗原发性肾病综合征的疗效及对肾功能的影响

Analysis of the effects of hyperbaric oxygen as adjuvant therapy on primary nephrotic syndrome and renal function

目的:分析高压氧辅助治疗原发性肾病综合征的疗效及对肾功能的影响。方法:选取2020年1月至2021年6月临沂市中心医院收治的原发性肾病综合征患者92例,根据治疗方式将其分为对照组( n=46)与观察组( n=46)。对照组给予常规治疗,观察组在常规治疗基础上辅以高压氧治疗。比较2组患者治疗前后血脂相关指标、炎性因子水平、肾功能的变化,并发症发生情况,以及临床治疗效果。 结果:治疗前,2组患者的血脂相关指标、炎性因子水平及肾功能指标比较差异无统计学意义( P>0.05);经治疗后,2组患者各指标均有所改善。治疗后,观察组胆固醇及三酰甘油水平较对照组明显降低( P<0.05);观察组白细胞介素1、白细胞介素6及肿瘤坏死因子α水平均明显低于对照组( P<0.05)。观察组治疗总有效率[93.48%(43/46)]明显高于对照组[76.09%(35/46)],差异有统计学意义( P<0.05)。观察组并发症的发生率[4.35%(2/46)]明显低于对照组[19.57%(9/46)],差异有统计学意义( P<0.05)。治疗后观察组血肌酐、尿素氮及24 h尿蛋白定量均较对照组明显降低,血清白蛋白水平较对照组明显升高,差异均有统计学意义( P<0.05)。 结论:高压氧辅助治疗能有效降低原发性肾病综合征患者的血脂水平,减轻炎症反应,提高临床治疗效果,减少并发症,改善肾功能。

Objective To analyze the effects of hyperbaric oxygen(HBO)as adjuvant therapy on primary nephrotic syndrome(PNS)and renal function.Methods A total of 92 PNS patients admitted to the Linyi Central Hospital from January 2020 to June 2021 were selected and divided into control group(n=46)and observation group(n=46)according to different treatment methods.The control group was given conventional treatment,and the observation group was given HBO on this basis of the treatment in the control group.The changes in the blood lipid-related indexes,inflammatory factor levels,and renal function in the two groups were compared before and after treatment,and the incidence of complications and the clinical therapeutic effect after treatment were observed.Results Before treatment,there were no significant difference in blood lipid-related indexes,inflammatory factor levels,or renal function indexes between the two groups.After treatment,the above-mentioned indexes in both groups were all improved.The levels of cholesterol(CHOL),triglyceride(TG),and the inflammatory factors including IL-1,IL-6,and TNF-αin the observation group were significantly lower than those in the control group(P<0.05).The total effective rate in the observation group[93.48%(43/46)]was higher than that in the control group[76.09%(35/46)],with statistically significant difference(P<0.05).The incidence of complications in the observation group[4.35%(2/46)]was significantly lower than that in the control group[19.57%(9/46)],with statistically significant difference(P<0.05).After treatment,the serum creatinine,urea nitrogen,and 24-hour urinary protein quantification in the observation group were lower than those in the control group,and the serum albumin level in the observation group was higher than that in the control group,and all the differences were statistically significant(P<0.05).Conclusion HBO as adjuvant therapy can improve the clinical therapeutic effect and enhance renal function,by effectively reducing the blood lipid level and inflammatory response and reducing complications,which is worth further popularization in clinical practice.