补气通滞方联合丁苯酞治疗气虚血瘀型短暂性脑缺血发作临床观察

Clinical Observation on Benefiting Qi and Clearing Stagnation Prescription Combined with Butylphthalide in the Treatment of Transient Ischemic Attack with Qi Deficiency and Blood Stasis

目的研究补气通滞方联合丁苯酞治疗气虚血瘀型短暂性脑缺血发作的临床效果。方法以沈阳市第二中医医院2019年6月—2020年6月收治的64例短暂性脑缺血发作患者为研究对象,采用随机数字表法分为参照组(给予丁苯酞治疗,32例)与观察组(在参照组基础上加用补气通滞方治疗,32例),对比分析不同治疗方法的应用效果。结果观察组治疗总有效率为93.75%(30/32),明显高于参照组的75.00%(24/32)(P<0.05);治疗后观察组PCT(0.41±0.16)ng/L与CRP(14.56±5.22)ng/L均低于参照组的(1.42±0.24)ng/L、(20.13±5.26)ng/L(P<0.05);观察组复发率3.13%(1/32)、脑梗死发生率0,均低于参照组的21.88%(7/32)、12.50%(4/32),差异有统计学意义(P<0.05);而2组病死率比较,差异无统计学意义(P>0.05)。结论联合治疗可有效改善患者病情,降低患者炎性反应,预防脑梗死发生,减少复发率,其治疗效果显著,值得推广。

Objective To study the clinical effect of benefiting qi and clearing stagnation prescription combined with butylphthalide in the treatment of transient ischemic attack of qi deficiency and blood stasis type.Methods A total of 64 patients with transient ischemic attack admitted to Shenyang Second Hospital of Traditional Chinese Medicine from June 2019 to June 2020 were randomly divided into the control group(32 cases were treated with butylphthalide)and the observation group(32 cases were treated with benefiting qi and clearing stagnation prescription)by the number table method.The application effects of different treatment methods were compared and analyzed.Results The total effective rate was 93.75%(30/32)in the observation group,which was significantly higher than 75.00%(24/32)in the control group(P<0.05).After treatment,PCT(0.41±0.16)ng/L and CRP(14.56±5.22)ng/L in the observation group were both lower than those in the control group(1.42±0.24)ng/L and(20.13±5.26)ng/L(P<0.05).The recurrence rate(3.13%,1/32)and the incidence of cerebral infarction(0)in the observation group were lower than those in the control group(21.88%,7/32)and(12.50%,4/32),and the difference was statistically significant(P<0.05).The difference in the mortality between the two groups was not statistically significant P(>0.05).Conclusion Combined therapy can effectively improve the patient’s condition,reduce the patient’s inflammatory response,prevent the occurrence of cerebral infarction,reduce the recurrence rate,has significantly therapeutic effect,and is worthy of promotion.