热毒宁联合头孢类治疗儿童支气管炎的效果研究

Study on the Effect of Reduning Combined with Cefoxitin in the Treatment of Chil⁃dren with Bronchitis

目的探讨热毒宁联合头孢西丁在儿童支气管炎患儿中的效果。方法选取2019年1月—2020年1月就诊于酒钢医院的94例支气管炎患儿,按随机数表法分成两组,各47例。其中对照组给予常规治疗+头孢西丁,观察组于对照组基础上加以热毒宁注射液,连续治疗1周。比较两组临床疗效、症状消失时间、炎性因子水平、肺功能、不良反应。结果观察组治疗总有效率为91.49%,较对照组的76.60%高,差异有统计学意义(χ^(2)=3.887,P=0.049);与对照组相比,观察组各项症状消失时间较短,差异有统计学意义(P<0.05);治疗前,两组白介素-6(IL-6)、白介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、用力肺活量(FVC)、第1秒用力呼气量(FEV1)、呼气流量峰值(PEF)相比,差异无统计学意义(P>0.05);治疗后,观察组各项炎性因子水平均较对照组低,各项肺功能指标均较对照组高,差异有统计学意义(P<0.05);两组不良反应差异无统计学意义(P>0.05)。结论热毒宁联合头孢西丁在支气管炎患儿治疗中效果确切,可加快患儿症状消失,控制其机体的炎性反应,促进肺功能恢复,且无严重不良反应,安全可行。

Objective To investigate the effect of Reduning combined with cefoxitin in children with bronchitis.Methods A total of 94 children with bronchitis who were treated in Jiugang Hospital from January 2019 to January 2020 were selected and divided into two groups according to the random number table method,with 47 cases in each group.Among them,the control group was given conventional treatment+cefoxitin,and the observation group was given Reduning injection on the basis of the control group for 1 week.The clinical efficacy,symptom disap⁃pearance time,inflammatory factor levels,pulmonary function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.49%,which was higher than that of the control group 76.60%,the difference was statistically significant(χ^(2)=3.887,P=0.049).Compared with the control group,the disappearance time of various symptoms in the observation group was shorter,the difference was statistically significant(P<0.05).Before treatment,interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1)and peak expiratory flow(PEF)in the two groups had no statistically significant difference(P>0.05).After treatment,the levels of various inflammatory factors in the observation group were lower than those in the control group,and all the pulmonary function indexes were higher than those in the control group,the difference was statistically significant(P<0.05).The adverse reactions of the two groups were similar,the difference was not statistically significant(P>0.05).Conclusion Reduning combined with cefoxitin is effective in the treatment of children with bronchitis,which can speed up the disappearance of symptoms,control the inflammatory response of the body,and promote the recovery of lung function,without se⁃rious adverse reactions,which is safe and feasible.