Na^(+)/K^(+)-ATPaseβ亚基研究进展

Research Progress of Na^(+)/K^(+)-ATPβSubunit

Na^(+)/K^(+)-ATP酶(Na^(+)/K^(+)-ATPase,NKA)是细胞膜上主要由α、β亚基组成的异二聚体,具有酶的活性和转运功能。α为催化亚基、β为调节亚基。其中α亚基研究的较为广泛。随着研究的深入,近年来对β亚基有了许多新的认识。β亚基不仅参与细胞内外Na^(+)/K^(+)交换的离子泵功能,还参与细胞连接和信号转导功能。深入研究β亚基分子结构特征、功能为疾病的发生发展及诊断等提供实验依据。

The Na^(+)/K^(+)-ATPase(Na^(+)/K^(+)-ATPase,NKA)is a heterodimer mainly composed ofαandβsubunits on the cell membrane,with enzymatic activity and transport function.Theαis the catalytic subunit andβis the regulatory subunit.Theαsubunit has been widely studied.With the deepening of research,many new understandings ofβsubunit have been obtained in recent years.Theβsubunit not only participates in the ion pump function of Na^(+)/K^(+)exchange inside and outside the cell,but also participates in the function of cell connection and signal transduction.In-depth study of the molecular structure characteristics and functions ofβsubunits to provide experimental basis for the occurrence,development and diagnosis of diseases.