慢性阻塞性肺疾病药物疗法简要概述

A Brief Overview of Pharmacotherapy for Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease, COPD)是一种可预防和可治疗的慢性气道疾病,伴有持续呼吸道症状和进行性气道阻塞。COPD的发病机制较为复杂,发病率和死亡率呈逐年上升的趋势,临床表现主要为咳嗽、咳痰、呼吸困难、喘息和胸闷。药物治疗为主要方式,现有药物有支气管扩张剂、糖皮质激素、联合用药、选择性磷酸二酯酶抑制剂、抗菌药等,均能有效缓解症状,控制病程发展,改善患者生活质量。

Chronic Obstructive Pulmonary Disease(COPD) is a preventable and treatable chronic disease with persistent respiratory symptoms and progressive airway obstruction. The pathogenesis of COPD is complex, and the incidence and mortality are increasing year by year. The main clinical manifestations of COPD are cough, expectoration, dyspnea, wheezing and chest tightness. Bronchodilators, glucocorticoids, combination drugs, selective phosphodiesterase inhibitors,antibacterial drugs, etc., are the main pharmacotherapy, which can be the effective maintenance treatment of bronchospasm associated with COPD, reducing COPD exacerbation, and improving the quality of life of patients.