子宫内膜及肠道微生物在子宫内膜癌发病中的作用

The Role of Endometrial and Intestinal Microbiome in the Pathogenesis of Endometrial Carcinoma

子宫内膜癌(endometrioid carcinoma,EC)是妇科三大恶性肿瘤之一,近年来,随着高通量测序、高分辨率成像技术的不断成熟,子宫内膜和肠道微生物的组成和变动与EC相关性的探讨逐步增多。目前研究表明,患病或亚健康状态下子宫内膜微生物变化可以产生白细胞介素和肿瘤坏死因子等促炎分子,影响子宫内膜细胞增殖。肠道微生物失调可能通过干扰具有β-葡萄糖醛酸酶的肠道微生物代谢影响雌激素水平,以此诱发子宫内膜不典型增生或癌变。综述子宫内膜和肠道微生物在EC发病中的作用,并讨论基于子宫内膜及肠道微生物的干预能否为EC的治疗及管理提供新的研究思路和方向。

Endometrioid carcinoma(EC)is one of the three major gynecological malignancies.In recent years,with the development of high-throughput sequencing and high-resolution imaging technology,the correlation between the composition and changes of endometrioid and intestinal microbiota and EC has been increasing gradually.Current studies have shown that changes in endometrial microorganisms under disease or sub-health state can produce pro-inflammatory molecules,such as interleukin and tumor necrosis factor,and affect endometrial cell proliferation.Intestinal dysbiosis may induce endometrial atypical hyperplasia or can ceration by interfering with the metabolism of intestinal microbiota withβ-glucuronase and thereby affecting estrogen levels.This article reviews the role of endometrium and intestinal microbiome in the pathogenesis of EC,and discusses whether the intervention based on endometrial and intestinal microflora can provide new research ideas and directions for the treatment and management of patients with EC.