不同来源外泌体中微小RNA在子痫前期的研究进展

Research Progress of MicroRNAs in Exosomes from Different Sources in Pre-Eclampsia

子痫前期(pre-eclampsia,PE)的发病机制至今尚未明确,而外泌体为PE发病机制的研究提供了新的方向。有研究表明外泌体在人体中广泛存在,红细胞、上皮细胞、间充质干细胞和胎盘细胞等细胞均可分泌外泌体。而这些不同来源外泌体中的微小RNA(microRNA,miRNA)被证明可以在PE的发生及预防、治疗中发挥一定的作用,例如胎盘来源外泌体中的miRNA可能与PE的发生息息相关,脐带血来源外泌体中的miRNA可能与胚胎发育有一定关系,而间充质干细胞来源外泌体中的miRNA则可能在PE的治疗中发挥重要作用。因此,探索这些miRNA及其外泌体来源对于明确PE的发病机制及靶向治疗具有重要意义。

The pathogenesis of pre-eclampsia(PE)remains unclear.However,exosomes provide a new direction for the study of the pathogenesis of PE.Studies have shown that exosomes are widespread in the human body,and cells such as red blood cells,epithelial cells,mesenchyme stem cells,and placental cells can secrete exosomes.The microRNAs(miRNAs)in exosomes from different sources have been shown to play a definite role in the occurrence and prevention of PE.For example,miRNAs in exosomes derived from the placenta may be closely related to the pathogenesis of PE,and miRNAs in cord blood-derived exosomes may have a certain relationship with embryonic development.While miRNAs in mesenchyme stem cell-derived exosomes may play an important role in the treatment of PE.These miRNAs in exosomes from diverse sources are associated with the occurrence and development of PE.Therefore,it is important to investigate the origin of these mirnas and their exosomes in order to understand the pathogenesis and target therapy of PE..