白脂素在2型糖尿病及其并发心脏、肾脏、视网膜病变中的作用研究进展

Research progress on the role of asprosin in type 2 diabetes and its complications of heart,kidney disease and retinopathy

2型糖尿病为糖尿病的最主要类型,约占糖尿病的90%。2型糖尿病易出现多种慢性并发症,导致器官功能障碍和衰竭,致残、致死率高,是严重威胁人类健康的主要疾病之一。白脂素是一种新发现的脂肪因子,具有调节血糖作用,与胰岛素抵抗、肥胖等糖尿病的危险因素相关;白脂素在糖尿病及其慢性并发症的发生、发展中起一定作用,可能成为2型糖尿病诊断和治疗的新靶点。本文就白脂素在2型糖尿病及其并发心脏、肾脏和视网膜病变中的作用研究进展进行综述,旨在为研究早期诊断糖尿病及其并发症的预测性生物化学指标提供新的方向。

Type 2 diabetes is the most important type of diabetes,accounting for 90%of diabetes.Type 2 diabetes is prone to a variety of chronic complications,leading to organ dysfunction and failure,and it has high disability and mortality,so it is one of the major diseases which seriously threaten human health.Asprosin is a newly discovered adipokine,which has the effect of regulating blood glucose,and it is related to the risk factors of diabetes such as insulin resistance and obesity.Asprosin plays a certain role in the occurrence and development of diabetes and its chronic complications,and it may be a new target for the diagnosis and treatment of type 2 diabetes.This paper reviews the research progress of the role of asprosin in type 2 diabetes and its associated heart,kidney disease and retinopathy,in order to provide a new direction for the study of predictive biochemical indicators for the early diagnosis of diabetes and its complications.