光动力疗法联合火针治疗中重度痤疮的临床疗效观察

Clinical observation of photodynamic therapy combined with fire acupuncture in treatment of moderate to severe acne

目的探究5-氨基酮戊酸(ALA)光动力联合火针治疗中重度痤疮的有效性与安全性。方法将2020年5月至2020年12月就诊于十堰市人民医院皮肤科的58例中重度痤疮患者作为研究对象。按照随机原则分为两组,治疗组29例予以火针预处理+ALA光动力治疗,2周治疗1次,共4次;对照组29例予以火针处理+多西环素治疗,口服多西环素每日2次,每次0.1 g,共8周;火针处理2周一次,共4次。治疗结束4周后对两组进行随访统计。比较两组疗效,评估两组治疗后的不良反应。结果治疗组临床总有效率明显高于对照组(79.31%vs.55.17%),差异有统计学意义(P<0.05);治疗后,治疗组和对照组患者痤疮综合分级系统(GAGS)评分均明显下降,治疗组下降程度大于对照组(P<0.05);治疗组和对照组治疗后均出现红斑、肿痛、色沉等不良反应,差异无统计学意义(P>0.05)。结论光动力联合火针疗法疗效优于多西环素联合火针疗法,两组即刻局部不良反应相当;光动力联合火针组不出现头晕、头痛、消化道症状等全身反应,是一种安全有效的治疗方式。

【Objective】To explore the efficacy and safety of ALA photodynamic therapy combined with fire acupuncture in the treatment of moderate to severe acne.【Methods】Sixty patients with moderate to severe acne in the dermatology department of our hospital from May 2020 to December 2020 were randomly divided into two groups.Twenty-nine patients in the treatment group were treated with fire needle pretreatment+ALA photodynamic therapy,once in 2 weeks,a total of 4 times;29 cases in the control group were treated with fire acupuncture+doxycycline,oral doxycycline twice a day,0.1 g each time,for 8 weeks;fire needle treatment once every 2 weeks,a total of 4 times.After 4 weeks of treatment,the two groups were followed up.The curative effects of the two groups were compared.The adverse reactions of the two groups after treatment were evaluated.【Results】The total effective rate was 79.31%in the treatment group and 55.17%in the control group(P<0.05).After treatment,the scores of acne comprehensive grading system(GAGS)in the treatment group and the control group decreased significantly,and the degree of decline in the treatment group was greater than that in the control group(P<0.05).After treatment,both groups had adverse reactions such as erythema,swelling and pain and color sink,and there were no statistically significant difference.【Conclusion】The curative effect of the treatment group is better than that of the control group.The safety of the treatment group was better than that of the control group.ALA photodynamic therapy combined with fire acupuncture in the treatment of moderate to severe acne is worthy of clinical promotion.