阿司匹林肠溶片联合低分子肝素治疗习惯性流产患者的效果

Effects of Aspirin enteric-coated tablets combined with low molecular weight heparin in treatment of habitual abortion

目的:观察阿司匹林肠溶片联合低分子肝素治疗习惯性流产患者的效果。方法:选取2020年8月至2021年11月该院收治的60例习惯性流产患者进行前瞻性研究,采用随机数字表法分为观察组和对照组各30例。对照组采用低分子肝素治疗,观察组在对照组基础上联合阿司匹林肠溶片治疗,比较两组治疗前后凝血功能指标[D-二聚体(D-D)、凝血酶时间(TT)]水平、血液流变学指标[血细胞比容(HCT)、红细胞沉降率(ESR)、血浆黏度(PV)]水平、妊娠结局、分娩孕周、不良反应发生率。结果:治疗后,观察组D-D、TT水平均低于对照组,差异有统计学意义(P<0.05);观察组HCT、ESR、PV水平均低于对照组,差异有统计学意义(P<0.05);观察组分娩孕周长于对照组,差异有统计学意义(P<0.05);观察组足月产率和活产率均高于对照组,流产率低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:阿司匹林肠溶片联合低分子肝素治疗习惯性流产患者可改善患者凝血功能、血液流变学指标,延长分娩孕周,改善妊娠结局,其效果优于低分子肝素单药治疗。

Objective:To observe effects of Aspirin enteric-coated tablets combined with low molecular weight heparin in treatment of habitual abortion.Methods:60 patients with habitual abortion who were admitted to our hospital from August 2020 to November 2021 were selected for the prospective study and were divided into observation group and control group by using the random number table method,30 cases in each.The control group was treated with low molecular weight heparin,while the observation group was treated with aspirin enteric-coated tablets on the basis of that of the control group.The levels of blood coagulation function indexes[D-dimer(D-D),thrombin time(TT)],the hemorheology index levels[hematocrit(HCT),erythrocyte sedimentation rate(ESR),plasma viscosity(PV)],the pregnancy outcome,the gestational age at delivery,and incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of D-D and TT in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of HCT,ESR and PV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The gestational age at delivery in the observation group was longer than that in the control group,and the difference was statistically significant(P<0.05).The term birth rate and the live birth rate in the observation group were higher than those in the control group,the abortion rate was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:Aspirin enteric-coated tablets combined with low molecular weight heparin in the treatment of the patients with habitual abortion can improve the coagulation function and the hemorheology index levels,prolong the gestational age at delivery,and improve the pregnancy outcome without increasing the risk of adverse reactions.