空气泵驱动与氧驱动雾化吸入布地奈德治疗AECOPD患者的效果比较

Comparison of effects of air pump driven and oxygen driven atomization of Budesonide in treatment of patients with AECOPD

目的:比较空气泵驱动与氧驱动雾化吸入布地奈德治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的效果。方法:回顾性分析2018年5月至2019年11月该院收治的73例AECOPD患者的临床资料,按照治疗方法不同分为对照组36例和观察组37例。对照组使用氧驱动雾化吸入布地奈德治疗,观察组使用空气泵驱动雾化吸入布地奈德治疗,比较两组治疗前、雾化结束30 min CAT评分、胸肺顺应性指标(胸廓顺应性、肺顺应性)水平、血气指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]水平。结果:治疗后,两组CAT评分均低于治疗前,但组间比较,差异无统计学意义(P>0.05);两组胸廓顺应性和肺顺应性水平均高于治疗前,但组间比较,差异无统计学意义(P>0.05);治疗后,两组PaCO_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组PaO_(2)水平均高于治疗前,但组间比较,差异无统计学意义(P>0.05)。结论:空气泵驱动与氧驱动雾化吸入布地奈德治疗AECOPD患者的总体效果相当,但空气泵驱动雾化吸入治疗可降低PaCO_(2)水平,效果优于氧驱动雾化吸入治疗。

Objective:To compare effects of air pump driven and oxygen driven atomization of Budesonide in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The clinical data of 73 patients with AECOPD admitted to our hospital from May 2018 to November 2019 were retrospectively analyzed,and were divided into control group(36 cases)and observation group(37 cases)according to different treatment methods.Both groups received Budesonide aerosol inhalation therapy.The control group was treated with Oxygen driven atomization,while the observation group was treated with air pump driven atomization.The CAT scores,the thoracic and lung compliance index levels(thoracic compliance,lung compliance),the blood gas indicator levels[arterial carbon dioxide partial pressure(PaCO_(2)),arterial oxygen partial pressure(PaO_(2))]were compared between the two groups before and after the treatment.Results:After the treatment,the CAT scores in both groups were lower than those before the treatment;however,there was no significant difference between the groups(P>0.05).The levels of thoracic compliance and lung compliance in the two groups were higher than those before the treatment;however,there was no significant difference between the two groups(P>0.05).After the treatment,the levels of PaCO_(2) in the two groups were lower than those before the treatment,that of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Further,the levels of PaO_(2) in the two groups were higher than those before the treatment;however,there was no significant difference between the two groups(P>0.05).Conclusions:The overall treatment effects of air pump driven and oxygen driven atomization of Budesonide in the treatment of the AECOPD patients are comparable;however,air pump driven atomization therapy can reduce the PaCO_(2) level.Moreover,it is superior to oxygen driven atomization therapy.