内镜下金属钛夹止血与注射止血药物治疗非静脉曲张性上消化道出血患者的效果比较

Comparison of effects of endoscopic metal titanium clips hemostasis and injection of hemostatic drugs in treatment of patients with non-variceal upper gastrointestinal bleeding

目的:比较内镜下金属钛夹止血与注射止血药物治疗非静脉曲张性上消化道出血(NVUGIB)患者的效果。方法:选取2019年6月至2020年6月该院收治的66例NVUGIB患者进行前瞻性研究,按照随机数字表法分为对照组和研究组各33例。对照组实施内镜下注射止血药物治疗,研究组实施内镜下金属钛夹止血治疗,比较两组临床疗效、临床症状消失时间,治疗前后血红蛋白(Hb)水平、红细胞计数(RBC)和凝血酶原时间(PT),以及再出血率。结果:研究组治疗总有效率为90.91%,高于对照组的66.67%,差异有统计学意义(P<0.05);研究组便血和呕血等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组Hb水平和RBC均高于治疗前,且研究组高于对照组,对照组PT短于治疗前,但研究组长于对照组,差异有统计学意义(P<0.05);研究组再出血率为0,低于对照组的18.18%,差异有统计学意义(P<0.05)。结论:内镜下金属钛夹止血治疗NVUGIB患者,可提高治疗总有效率和Hb水平、RBC,缩短临床症状消失时间,以及降低再出血率,效果优于内镜下注射止血药物治疗。

Objective:To compare effects of endoscopic metal titanium clips hemostasis and injection of hemostatic drugs in treatment of patients with non-variceal upper gastrointestinal bleeding(NVUGIB).Methods:66 NVUGIB patients admitted to our hospital from June 2019 to June 2020 were selected for the prospective study and were divided into control group and study group according to the random number table method,33 cases in each group.The control group was treated with endoscopic injection of hemostatic drugs,while the study group was treated with endoscopic metal titanium clips hemostasis.The clinical efficacy,the clinical symptom disappearance time,the levels of hemoglobin(Hb)level,red blood cell count(RBC)and prothrombin time(PT),and the rebleeding rate were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 90.91%,which was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).The clinical symptom disappearance time such as hematochezia and hematemesis in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Hb and RBC in the two groups were higher than those before the treatment,and those of the study group were higher than those of the control group;the PT in the control group was shorter than before the treatment,but that of the study group was longer than that of the control group;and the differences were statistically significant(P<0.05).Further,the rebleeding rate in the study group was 0,which was lower than 18.18%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Endoscopic metal titanium clips hemostasis in the treatment of the NVUGIB patients can improve the total effective rate,improve the Hb level and RBC,shorten the clinical symptom disappearance time,and reduce the rebleeding rate.Moreover,it is superior to endoscopic injection of hemostatic drugs.