SIRT家族在结直肠癌中的研究进展

Research progress of SIRT family in colorectal cancer

SIRT(Sirtuins)是一类高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖的Ⅲ类去乙酰化酶,包括SIRT1-7共7名家族成员,主要通过调节代谢、介导自噬和维持遗传稳定性在正常细胞内稳态中发挥重要作用。在结直肠癌的发生发展中,SIRT能够通过去乙酰化组蛋白和非组蛋白来调控基因的表达,调节细胞的代谢、增殖以及凋亡等过程,进而影响肿瘤细胞的增殖、迁移和侵袭,在CRC中发挥促癌或抑癌的作用。本文综述了SIRT家族在CRC发生发展过程中的生物学作用,旨在更好地了解其作用机制,为CRC的治疗提供新的探索途径。

Sirtuins(SIRT) is a highly conserved nicotinamide adenine dinucleotide(NAD+) dependent class Ⅲ deacetylase, including seven family members, SIRT1-7. SIRT plays an important role in normal cell homeostasis by regulating metabolism, mediating autophagy and maintaining genetic stability. In the occurrence and development of colorectal cancer, SIRT can regulate cell metabolism, proliferation and apoptosis and other processes by regulating gene expression by deacetylating histones and non-histone proteins, thereby affecting the proliferation, migration and invasion of tumor cells, playing a tumor-promoting or tumor-suppressing role in CRC. This paper reviews the biological function of SIRT family in the development of colorectal cancer in order to better understand its mechanism of action and provide a new exploration way for the treatment of colorectal cancer.