MCS+UPP和LDP单采血小板的效果评价

Evaluation of the effect of MCS+UPP and LDP for apheresis platelets

目的探讨MCS+通用血小板采集程序(UPP)及少白血小板采集程序(LDP)单采血小板的效果。方法2020年11月至2021年5月,该中心机采成分科招募120例男性固定无偿献血者为研究对象,随机分成UPP组和LDP组,每组各60例,LDP组采用LDP采集2个治疗量血小板,UPP组采用UPP采集2个治疗量血小板。比较两组采集参数,包括抗凝剂使用量、循环血量、采血前后血小板计数(PLT)、采血前血细胞比容(Hct);比较两组采集效果,包括血小板采集效率(CE)、血小板采集速率(CR)、每小时血小板采集量及采集时间;采血后对采集的血小板质量进行检测;比较两组采集血小板的冲红率、低压报警率、献血不良反应发生率。结果UPP组抗凝剂使用量和循环血量高于LDP组,差异有统计学意义(P<0.05)。LDP组采集时间长于UPP组,CE、CR、每小时血小板采集量低于UPP组,差异有统计学意义(P<0.05)。120例献血者成功采集的每袋血小板均符合《全血及成分血质量要求:GB18469-2012》相关标准。LDP组冲红率、低压报警率和献血不良反应发生率均高于UPP组,差异有统计学意义(P<0.05)。结论UPP提高了血小板采集效率,减少了冲红率、低压报警率和献血不良反应的发生率,优化了采集过程,保障了血液质量和血液安全,能更好地服务于无偿献血者。

Objective To investigate the effect of MCS+universal platelet collection program(UPP)and low white platelet collection program(LDP)for apheresis platelets.Methods From November 2020 to May 2021,a total of 120 male regular unpaid blood donors were recruited as research subjects in the department of mechanical collection of the center,and they were randomly divided into the UPP group and the LDP group,with 60 cases in each group.The LDP group used the LDP to collect 2 therapeutic platelets,and the UPP group used the UPP to collect 2 therapeutic platelets.The acquisition parameters were compared between the two groups,including the amount of anticoagulant used,circulating blood volume,platelet count(PLT)before and after blood collection,and hematocrit(Hct)before blood collection.The collection effects of the two groups were compared,including platelet collection efficiency(CE),platelet collection rate(CR),platelet collection volume per hour and collection time.Checked the quality of the collected platelets after blood collection.The red flush rate,low pressure alarm rate,and incidence of blood donation adverse reactions were compared between the two groups.Results The amount of anticoagulant used and circulating blood volume in the UPP group were higher than those in the LDP group,and the differences were statistically significant(P<0.05).The collection time in the LDP group was longer than that in the UPP group,and the CE,CR and platelet collection volume per hour were lower than those in the UPP group,and the differences were statistically significant(P<0.05).Each bag of platelets successfully collected from 120 blood donors met the relevant standards of"Quality Requirements for Whole Blood and Component Blood:GB18469-2012".The red flush rate,low pressure alarm rate and the incidence of blood donation adverse reactions in the LDP group were higher than those in the UPP group,and the differences were statistically significant(P<0.05).Conclusion The UPP improves platelet collection efficiency,reduces red flush rate,low pressure alarm rate and the incidence of blood donation adverse reactions,optimizes the collection process,ensures blood quality and blood safety,and can better serve unpaid blood donors.