单相抑郁症患者各脑叶CT检查参数的改变及影像学分析

CT parameter changes and imaging analysis of each cerebral lobe in patients with monophasic depression

目的通过各脑叶CT检查参数的改变分析单相抑郁症患者的影像学改变。方法纳入2019年6月至2021年6月绍兴市第七人民医院放射科室接诊的单相抑郁症患者100例为观察组,同期选取身体检查为健康者100例为对照组,均给予颅脑CT扫描,对两组患者各脑叶CT值进行对比分析。结果脑叶CT值:观察组左额叶(40.88±2.01)HU、左颞叶(40.21±3.01)HU均低于对照组(t_(左额叶)=2.94,P=0.004;t_(左颞叶)=3.29,P=0.001),观察组右额叶(40.09±2.52)HU、右颞叶(44.93±3.03)HU与对照组差异无统计学意义(t_(右额叶)=1.89,P=0.060;t_(右颞叶)=1.89,P=0.060)。两组左右枕叶、顶叶CT值差异无统计学意义(P>0.05)。观察组脑叶CT值与年龄、Hamilton汉密尔顿抑郁量表(HAMD-24)评分、病程、发作次数的单因素相关分析结果显示,左、右额叶CT值与年龄(-0.441、-0.211)、病程(-0.445、-0.191)呈负相关(P<0.05);左、右额叶CT值与HAMD-24评分、发作次数无明显相关性(P>0.05);左右颞叶(-0.207、-0.213)、左右枕叶(-0.185、-0.195)、左右顶叶(-0.185、-0.180)CT值均与年龄呈负相关(P<0.05);左右颞叶、左右枕叶、左右顶叶CT值与病程、HAMD-24评分、发作次数无明显相关性(P>0.05)。结论单相抑郁症患者左右额叶、左颞叶存在萎缩现象,萎缩程度与患者病程存在密切关系,可作为中枢神经系统退行性疾病的影像学诊断参考。

Objective To analyze the imaging changes of patients with monophasic depression based on the changes in CT parameters of each cerebral lobe.Methods A total of 100 patients with monophasic depression who received treatment in Department of Radiology,Shaoxing 7th People's Hospital between June 2019 and June 2021 were included in the observation group.An additional 100 healthy individuals who concurrently received physical examination were included in the control group.CT scan of the brain was performed in all participants.CT value of each cerebral lobe was compared between the two groups.Results CT values of the left frontal lobe and left temporal lobe in the observation group were(40.88±2.01)HU and(40.21±3.01)HU,respectively,which were significantly lower than those in the control group(t_(left frontal lobe)=2.94,P=0.004;t_(left temporal lobe)=3.29,P=0.001).CT values of the right frontal lobe and right temporal lobe in the observation group were(40.09±2.52)HU and(44.93±3.03)HU,respectively.There were no significant differences in CT values of the right frontal lobe and right temporal lobe between the two groups(t_(right frontal lobe)=1.89,P=0.060;t_(right temporal lobe)=1.89,P=0.060).There were no significant differences in CT values of the left and right occipital lobes and the left and right parietal lobes between the two groups(all P>0.05).One-way analysis of variance revealed that the CT values of the left and right frontal lobes were negatively correlated with age(-0.441,-0.211)and course of disease(-0.445,-0.191)(both P<0.05);the CT values of the left and right frontal lobes were not significantly correlated with 24-item Hamilton Depression Rating Scale score and the number of attacks(all P>0.05).The CT values of the left and right temporal lobes(-0.207,-0.213),the left and right occipital lobes(-0.185,-0.195)and the left and right parietal lobes(-0.185,-0.180)were negatively correlated with age(all P<0.05).The CT values of the left and right temporal lobes,the left and right occipital lobes,and the left and right parietal lobes were not significantly correlated with course of disease,24-item Hamilton Depression Rating Scale score,and the number of attacks(all P>0.05).Conclusion The left and right frontal lobe and the left temporal lobe are atrophic in patients with monophasic depression.The degree of atrophy is closely related to the course of disease.Therefore,these findings can be used as a reference for imaging diagnosis of degenerative diseases of the central nervous system.