摘要
患者男,49岁,面部丘疹伴声嘶1年,吞咽困难2个月。查体见面颈部、躯干百余粒肤色、蜡样光泽丘疹,舌体肿大;实验室检查示:血清IgG升高,M蛋白(+)。皮损组织病理示:真皮内大量红染物质,刚果红(+),偏振光显微镜下可见苹果绿色双折光,Ⅳ型胶原(+);骨髓活检符合多发性骨髓瘤表现。诊断:原发性系统性淀粉样变。
A 49-year-old male presented with facial papules and hoarseness for one year,and dysphagia for two months.There were more than 100 fresh-color waxy papules on the face,neck and trunk,the tongue was enlarged.The serum IgG was elevated and M protein was positive.Histopathological examination demanstrated eosinophilic homogenous material in the dermis,which was positive for Congo red with apple-green birefringence on polarized light and CollagenⅣ.Bone marrow biopsy revealed as multiple myeloma.The diagnosis of primary systemic amyloidosis with multiple myeloma was made.
作者
张曼曼
李小红
张宇飞
闻娟
杨秋萍
张亚利
于建斌
ZHANG Manman;LI Xiaohong;ZHANG Yufei;WEN Juan;YANG Qiuping;ZHANG Yali;YU Jianbin(Department of Dermatology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Dermatology,Shangqiu Municipal Hospital,Shangqiu 476100,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2022年第7期824-826,共3页
The Chinese Journal of Dermatovenereology