摘要
钠-葡萄糖共转运蛋白1(SGLT-1)是钠-葡萄糖共转运家族的一员,主要参与机体葡萄糖的重吸收。近年来,多项研究发现,SGLT-1蛋白可在心脏中表达,且表达水平与心血管疾病的发生发展密切相关,抑制SGLT-1过度表达可能对心血管疾病有保护作用。文章主要就SGLT-1在病理性心肌肥厚、缺血性心脏病、糖尿病心肌病、心律失常和心力衰竭等疾病过程中的作用进行综述,并探讨SGLT-1作为心血管疾病新的治疗靶点的潜力。
Sodium-glucose co-transporter 1(SGLT-1)is a member of the sodium-glucose co-transporter family and is mainly involved in the reabsorption of glucose in the body.In recent years,many studies have found that SGLT-1 protein can be expressed in the heart,and the expression level is closely related to the occurrence and development of cardiovascular disease.Inhibiting the overexpression of SGLT-1 may have a protective effect on cardiovascular disease.This article mainly reviews the role of SGLT-1 in pathological cardiac hypertrophy,ischemic heart disease,diabetic cardiomyopathy,arrhythmia and heart failure,and discusses SGLT-1 as a new therapeutic target for cardiovascular diseases.potential.
作者
周冰青(综述)
杨国康(审校)
Zhou Bingqing;Yang Guokang(Wuhan University of Science and Technology,Hubei Province,Wuhan 430000,China;不详)
出处
《疑难病杂志》
CAS
2022年第8期889-892,共4页
Chinese Journal of Difficult and Complicated Cases
基金
武汉市科学基金面上项目(WX19D64)。
