血清CRP、Fib与急性脑梗死患者颈动脉易损性斑块的相关性

Correlation between serum C-reactive protein,fibrinogen and carotid artery vulnerable plaque in patients with acute cerebral infarction

目的研究血清C反应蛋白(CRP)、纤维蛋白原(Fib)与急性脑梗死患者颈动脉易损性斑块的相关性。方法选取复旦大学附属上海市第五人民医院2020年5月至2021年5月收治的120例急性脑梗死患者为研究对象,根据颈动脉黑血磁共振成像(BB-MRI)检查颈动脉血管斑块稳定性的结果分为稳定组(n=73)和易损组(n=47),比较两组患者的年龄、性别、体质量(BMI)指数、合并疾病及血清CRP、Fib水平等一般资料,采用多因素Logistic回归分析法分析影响急性脑梗死患者颈动脉易损性斑块的独立危险因素,并采用Spearman等级相关系数分析血清CRP、Fib与急性脑梗死患者颈动脉易损性斑块的相关性。结果两组患者的年龄、性别、合并疾病、BMI指数、血脂、血糖、血压比较差异均无统计学意义(P>0.05);易损组患者的CRP、Fib水平分别为14.76±0.35、4.19±0.15,明显高于稳定组的10.83±0.29、3.15±0.21,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,CRP、Fib是影响急性脑梗死患者颈动脉易损性斑块的独立危险因素(P<0.05);经Spearman检验结果显示,CRP、Fib水平与急性脑梗死患者颈动脉易损性斑块呈正相关(r=2.81、1.92;P<0.05)。结论CRP、Fib水平与急性脑梗死患者颈动脉易损性斑块形成密切相关,可作为临床初筛易损斑块的血清标志物,有助于识别病情变化。

Objective To study the correlation between serum C-reactive protein(CRP),fibrinogen(Fib)and carotid artery vulnerable plaque in patients with acute cerebral infarction.Methods A total of 120 patients with acute cerebral infarction admitted to the Shanghai Fifth People's Hospital Affiliated to Fudan University from May 2020 to May 2021 were selected as the research objects.According to the results of carotid black blood magnetic resonance imaging(BB-MRI)examination of the stability of carotid vascular plaque,they were classified as stable group(n=73)and vulnerable group(n=47).The general data such as age,gender,body mass(BMI)index,co-morbidities,and serum CRP and Fib levels were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the independent risk factors of carotid artery vulnerable plaque in patients with acute cerebral infarction.Spearman's rank correlation coefficient was used to analyze the correlation between serum CRP,Fib and carotid artery vulnerable plaque in patients with acute cerebral infarction.Results There were no significant differences in age,gender,co-morbidities,BMI index,blood lipids,blood sugar,and blood pressure between the two groups(P>0.05).The CRP and Fib levels in the vulnerable group were 14.76±0.35,4.19±0.15,which was significantly higher than 10.83±0.29 and 3.15±0.21 of the stable group(P<0.05).Multivariate Logistic regression analysis showed that CRP and Fib were independent risk factors for carotid artery vulnerable plaque in patients with acute cerebral infarction(P<0.05).Spearman test showed that CRP and Fib levels were positively correlated with carotid artery vulnerable plaque in patients with acute cerebral infarction(r=2.81,1.92;P<0.05).Conclusion The levels of CRP and Fib are closely related to the formation of vulnerable plaques in the carotid artery in patients with acute cerebral infarction.They can be used as serum markers for the initial clinical screening of vulnerable plaques,and help to identify changes in the disease.