血清RBP4与青年男性急性心肌梗死的相关性

Correlation between serum retinol-binding protein 4 and acute myocardial infarction in young men

目的探讨血清视黄醇结合蛋白(RBP4)与青年男性急性心肌梗死的相关性。方法选取2019年5月至2020年5月深圳市龙岗中心医院心内科收治的40例青年男性心肌梗死患者(20~44岁)作为研究组,同时选取我院体检科25名健康男性(20~44岁)作为对照组,比较两组受检者的血清RBP4水平,采用多因素Logistic回归分析青年男性急性心肌梗死的相关因素,采用Spearman相关性分析RBP4与血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)的相关性。结果研究组患者的血清RBP4水平为(38.03±7.34)mg/mL,明显低于对照组的(46.10±8.59)mg/mL,差异有统计学意义(P<0.05);同时研究组患者的FPG、TG较对照组升高,HDL-C较对照组降低,差异均有统计学意义(P<0.05);经多因素Logistic回归分析结果显示,血清RBP4及HDL-C降低、FPG升高是青年男性发生急性心肌梗死的相关危险因素(P<0.05);经Spearman相关性分析结果显示,血清RBP4水平与HDL-C呈正相关性(r=0.259,P<0.05)。结论血清RBP4降低可能是青年男性发生急性心肌梗死的重要因素之一。

Objective To investigate the correlation of serum retinol-binding protein 4 with acute myocardial infarction in young male patients.Methods Forty young male patients with myocardial infarction(20 to 44 years old)admitted to Shenzhen Longgang Central Hospital from May 2019 to May 2020 were selected as the study group,and 25 healthy men(20 to 44 years old)were randomly selected as the control group,The serum RBP4 levels of the two groups were compared,and multivariate Logistic regression was used to analyze the related factors of acute myocardial infarction in young males.Spearman correlation was used to analyze the correlation between RBP4 and cardiovascular risk factors such as serum high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),and fasting blood glucose(FPG).Results The serum RBP4 level in the study group was(38.03±7.34)mg/mL,which was significantly lower than(46.10±8.59)mg/mL in the control group(P<0.05).FPG and TG in the study group were higher than those in the control group,while HDL-C was lower than those in the control group,with statistically significant differences(P<0.05).Multivariate Logistic regression analysis showed that the decrease of serum RBP4 and HDL-C and the increase of FPG were related risk factors of acute myocardial infarction in young males(P<0.05).Spearman correlation analysis showed that serum RBP4 level was positively correlated with HDL-C(r=0.259,P<0.05).Conclusion The decrease of serum retinol-binding protein 4 may be a major factor that associated with acute myocardial infarction in young males.