酸敏感离子通道与消化系统疾病关系的研究进展

Research progress in the relationship between acid-sensing ion channels and digestive system diseases

酸敏感离子通道(ASICs)是一类胞外质子作为配体激活的阳离子通道,是感受细胞外酸性变化的关键受体,广泛分布于生物体内,参与炎症、缺血、肿瘤增殖等涉及酸中毒的生理及病理过程,在疾病的发病过程中发挥着重要的作用。近年来,有许多研究表明ASICs与消化系统疾病关系密切,参与多种消化系统疾病的发生、发展过程。本文就ASICs与消化系统疾病的关系研究做一综述。

Acid-sensing ion channels(ASICs)are a kind of cation channels activated by extracellular protons as ligands,whch are key receptors for sensing extracellular acid changes and are widely distributed in organisms.They are involved in the physiological and pathological processes of inflammation,ischemia,tumor proliferation and other acidosis,and play an important role in the pathogenesis of diseases.In recent years,many studies have shown that ASICs are closely related to digestive diseases and participate in the occurrence and development of various digestive diseases.This paper reviews the relationship between ASICs and digestive diseases.