摘要
噻唑类化合物在抗菌、抗结核、抗癌、抗神经衰退性疾病等方面展现着巨大的用途。以对甲基苯酚为原料,通过取代、重排等过程合成目标化合物2-(4-甲基苯氧甲基)-4-(N-异丁基-N-乙酰基-氨甲基)-噻唑,并通过核磁等表征确认结构。同时,对该化合物的药理活性进行了研究,结果表明其对丁酰胆碱酯酶(BuChE)有较强的抑制活性,为开发新型阿尔兹海默症的治疗药物提供了思路。
Thiazole compounds have shown great uses in antibacterial,anti-tuberculosis,anti-cancer,and anti-neurodegenerative diseases.In this paper,the target compound 2-(4-Methylphenoxymethyl)-4-(N-isobutyl-N-acetyl-aminomethyl)-thiazole was synthesized by p-cresol through substitution,rearrangement and other reactions and the structure was confirmed by NMR.At the same time,the pharmacological activity of the compound was studied,and the results showed that it has a strong inhibitory activity on Bu Ch E,which provides ideas for the development of new therapeutic drugs for AD.
作者
黑延琳
于绪平
金剑炜
宋少奇
商甜波
罗艳娟
潘晓军
陈龙
徐慧婷
Hei Yanlin;Yu Xuping;Jin Jianwei;Song Shaoqi;Shang Tianbo;Luo Yanjuan;Pan Xiaojun;Chen Long;Xu Huiting(Zhejiang Medicine Co.,Ltd.,Shaoxing 312000,China;Zhejiang Engineering Research Center of Fat-soluble Vitamin,Shaoxing University,Shaoxing 312000,China;College of Chemeal Engineering,Shaoxing College of Arts and Sciences,Shaoxing 312000,China)
出处
《山东化工》
CAS
2022年第14期14-16,19,共4页
Shandong Chemical Industry
关键词
噻唑
合成
药理活性
阿尔兹海默症
thiazole
synthesis
pharmacological activity
alzheimer’s disease