泻肺活血化痰方联合西药治疗慢性阻塞性肺疾病急性加重期痰热郁肺夹瘀证临床研究

Clinical Study on Xiefei Huoxue Huatan Prescription Combined with Western Medicine for Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Syndrome of Phlegm-Heat Obstructing the Lung Complicated by Stasis

目的:观察泻肺活血化痰方联合西药治疗慢性阻塞性肺疾病(COPD)急性加重期痰热郁肺夹瘀证的临床疗效。方法:选取105例COPD急性加重期痰热郁肺夹瘀证患者,以随机数字表法分为观察组53例与对照组52例。对照组给予常规西药(噻托溴铵粉雾剂+盐酸莫西沙星片)治疗,观察组在对照组基础上给予泻肺活血化痰方治疗,2组均治疗7 d。比较2组临床疗效,以及治疗前后肺功能、细胞免疫功能和炎症因子水平。结果:观察组总有效率92.45%,高于对照组71.15%(P<0.05)。治疗后,2组肺功能、细胞免疫功能指标均较治疗前改善(P<0.05),观察组肺功能、细胞免疫功能指标均改善更明显(P<0.05)。治疗后,2组血清炎症因子水平均较治疗前降低(P<0.05),观察组血清炎症因子水平均低于对照组(P<0.05)。结论:泻肺活血化痰方联合西药治疗COPD急性加重期痰热郁肺夹瘀证疗效显著,有利于改善患者的肺功能,提高机体免疫功能,减轻炎症反应。

Objective:To observe the clinical effect of the therapy of Xiefei Huoxue Huatan prescription combined with western medicine on acute exacerbation of chronic obstructive pulmonary disease(COPD)with syndrome of phlegm-heat obstructing the lung complicated by stasis. Methods:A total of 105 patients with acute exacerbation of COPD with syndrome of phlegm-heat obstructing the lung complicated by stasis were selected and divided into the observation group(53 cases) and the control group(52 cases) by random number table method. The control group was treated with conventional western medicine, including tiotromine powder inhalation and Moxifloxacin hydrochloride tablets, and the observation group was additionally treated with Xiefei Huoxue Huatan prescription based on the treatment of the control group.Both groups were treated for seven days. The lung function,cellular immune function and inflammatory factors before and after treatment as well as the clinical effects were compared between the two groups.Results:The total effective rate was 92.45% in the observation group,higher than that of 71.15% in the control group(P<0.05). After treatment, the lung function and cellular immune function indexes in both groups were improved than those before treatment(P<0.05);the lung function and cellular immune function indexes in the observation group were better than those in the control group(P<0.05). After treatment,the levels of serum inflammatory factors in both groups were decreased when compared with those before treatment(P<0.05), and the levels of serum inflammatory factors in the observation group were lower than those in the control group(P<0.05). Conclusion: The therapy of Xiefei Huoxue Huatan prescription combined with western medicine has a significant effect on the treatment of acute exacerbation of COPD with syndrome of phlegm-heat obstructing the lung complicated by stasis,which helps improve the lung function of patients,enhance the immune function of the body,and reduce inflammation.