环氧二十碳三烯酸对机体影响的研究进展

Research progress on the effects of epoxyeicosenotrienoic acid on organism

花生四烯酸的细胞色素P450(cytochrome P450,CYP450)主要代谢物是环氧二十碳三烯酸(epoxyeicosatrienoic acids,EETs),在不同的脏器中都会发挥作用。可以舒张血管,防止组织纤维化,降低血压,抗炎从而改善脏器功能。近年来,应用转基因动物过表达CYP450表氧化酶或用可溶性环氧化物水解酶(soluble epoxide hydrolase,sEH)抑制剂也均证实提高体内EETs水平具有明显的脏器保护作用。本文对EETs在常见疾病中的作用机制进行分析和总结,也对未来EETs相关疾病的靶向治疗提出了展望。

Epoxyeicosatrienoic acids(EETs)are the main metabolites of cytochrome P450(CYP450)of arachidonic acid,which play a role in different organs.It can dilate blood vessels,prevent tissue fibrosis,decrease blood pressure,and improve organ function by anti-inflammatory.In recent years,it was confirmed that increasing the level of EETs in vivo has obvious viscera protective effect by using CYP450 surface oxidase over-expressed transgenic animals or soluble epoxide hydrolase(sEH)inhibitor.In this paper,the mechanism of EETs in common diseases was analyzed and summarized,and the prospect of targeted therapy for EETs related diseases in the future was proposed.