放疗诱导肿瘤细胞铁死亡的研究进展及治疗策略

Research progress and treatment strategy of ferroptosis induced by radiotherapy in tumor cells

肿瘤细胞固有的死亡抵抗机制是导致放疗抵抗的主要原因。铁死亡是一种铁依赖的脂质过氧化介导的新型调节性细胞死亡方式。研究发现:放疗具有诱导肿瘤细胞铁死亡的效能,尤其是在难治性肿瘤中发挥重要的作用,并可有效地改善患者预后和生存期。文章就放疗和肿瘤细胞铁死亡之间的关联性作一综述,并探讨针对肿瘤细胞铁死亡的联合治疗策略,对于改善肿瘤的治疗现状具有重要的临床价值。

The inherent death resistance mechanism of tumor cells is the main cause of radiotherapy resistance. Ferroptosis is a novel regulatory cell death mediated by iron dependent lipid peroxidation. Recent studies have found that radiotherapy can induce ferroptosis in tumor cells, especially in refractory tumors, which can effectively improve the prognosis and survival of patients. This article reviews the relationship between radiotherapy and ferroptosis of tumor cells, and discusses the combined treatment strategy for ferroptosis of tumor cells, which has important clinical value for improving the status of clinical tumor therapy.