替普瑞酮与心房颤动发展进程的研究综述

Geranylgeranylacetone and the development of atrial fibrillation

心房颤动是世界范围内最常见的年龄相关性心律失常,具有很高的发病率和病死率,与缺血性卒中、心力衰竭等疾病密切相关。因此,深入研究心房颤动的发生与进展机制,探索治疗心房颤动的有效方法显得尤为重要。替普瑞酮,别名戊四烯酮,是一种萜烯类化合物,被作为一种治疗消化系统溃疡的药物应用于临床。近年来的研究表明,替普瑞酮通过诱导热休克蛋白的产生而影响心房颤动的发生与进展。本文就替普瑞酮与心房颤动的发展进程进行综述。

Atrial fibrillation is the most common age-related arrhythmia worldwide,with a high morbidity and case fatality and is closely related to ischemic stroke,heart failure and other diseases.Therefore,it is particularly important to deeply study the mechanism of occurrence and progression of atrial fibrillation and explore the effective methods for the treatment.Geranylgeranylacetone,alias teprenone,is a terpene compound,which has been used in clinical practice as a treatment for ulcer in the digestive system.Recent studies have shown that geranylgeranylacetone affects the occurrence and progression of atrial fibrillation by inducing the production of heat shock protein.This review summarizes the correlation between geranylgeranylacetone and the development of atrial fibrillation.