丁苯酞及其衍生物药理学研究进展

Research progress on pharmacology of butylphthalide and its derivatives

丁苯酞(butylphthalide,NBP)是一种从芹菜种子中分离得到的无色或淡黄色黏稠油状成分。大量的实验研究证明NBP具有抗炎、抗氧化应激、保护血脑屏障、改善脑微循环和促进血管新生等作用,能够通过多种机制保护缺血性脑卒中患者的神经功能,改善患者的症状,并有助于患者长期恢复。因此,作为中国自主研发的一类新药,NBP已于2002年获国家食品药品监督管理局批准用于脑卒中患者的临床治疗。同时,由于NBP复杂的多靶点药理机制,其临床应用也逐渐增加,越来越多的研究发现其在阿尔茨海默病、血管性痴呆、帕金森病、自身免疫性疾病、抑郁症、创伤性中枢神经系统损伤等其他神经疾病的治疗也有明显效果,同时在非神经系统疾病如糖尿病、心肌梗死等同样具有显著的药理活性。因此,该文就NBP在神经系统疾病和非神经系统疾病中的研究进展进行全面综述,进一步了解NBP药理特性及作用机制的研究进展,为后续进行其相关机制靶点的研究提供思路。

The butylphthalide(NBP),a colorless or light yellow viscous oily component isolated from celery seeds,has the effects of anti-inflammation,anti-oxidative stress,protecting blood-brain barrier,improving cerebral microcirculation,and promoting angiogenesis.It can protect the neurological function of patients with ischemic stroke through a variety of mechanisms,improve the symptoms of patients,and contribute to the long-term recovery of them.Therefore,independently developed in China,NBP was approved by State Food and Drug Administration for the clinical treatment of stroke patients in 2002.At the same time,owing to the complex multi-target pharmacological mechanism,NBP has been frequently used in clinical practice.As frequently verified,it has obvious effects in the treatment of other neurological diseases such as Alzheimer′s disease,vascular dementia,Parkinson′s disease,autoimmune diseases,depression,traumatic central nervous system injury.Moreover,it demonstrates significant pharmacological effects on non-neurological diseases such as diabetes mellitus and myocardial infarction.Therefore,this study summarizes the research progress on roles of NBP in nervous system diseases and non-nervous system diseases,and the pharmacological characteristics and mechanisms of NBP,which is expected to lay a basis for research on related targets.