舒眠片联合唑吡坦治疗失眠症的临床研究

Clinical study on Shumian Tablets combined with zolpidem in treatment of insomnia

目的探讨舒眠片联合酒石酸唑吡坦片治疗失眠症的疗效。方法选择2020年9月—2021年9月在天津市泰达医院就诊的60例失眠患者,随机分为对照组和治疗组,每组各30例。对照组口服酒石酸唑吡坦片,10 mg/次,1次/d。在对照组的基础上,治疗组睡前口服舒眠片,3片/次,2次/d。两组治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者症状好转时间,匹兹堡睡眠质量调查表(PSQI)评分,血清因子白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平,及不良反应情况。结果治疗后,治疗组临床有效率为96.67%,明显高于对照组的73.33%(P<0.05)。治疗后,治疗组临床症状好转时间均早于对照组(P<0.05)。治疗后,两组PSQI评分、IL-1β、TNF-α水平均明显降低(P<0.05),且治疗后治疗组PSQI评分、IL-1β、TNF-α水平均明显低于对照组(P<0.05)。治疗期间,治疗组不良反应发生率(6.67%)明显低于对照组(16.67%,P<0.05)。结论舒眠片联合酒石酸唑吡坦片治疗失眠症疗效显著,可有效改善患者的睡眠质量,并能改善机体炎症反应,且安全有效。

Objective To investigate the therapeutic of Shumian Tablets combined with zolpidem in treatment of insomnia.Methods Patients(60 cases)with insomnia in Tianjin TEDA Hospital from September 2020 to September 2021 were randomly divided into control and treatment group,and each had 30 cases.Patients in the control group were po administered with Zolpidem Tartrate Tablets,10 mg/time,once daily.Patients in the treatment group were po administered with Shumian Tablets before bed on the basis of the control group,3 tablets/time,twice daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,the improvement time of symptoms,the PSQI scores,the levels of serum IL-1βand TNF-α,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 96.67%,which was significantly higher than that of the control group(73.33%)(P<0.05).After treatment,the time of improvement of clinical symptoms in the treatment group was earlier than that in the control group(P<0.05).After treatment,PSQI score,IL-1βand TNF-αlevels in 2 groups were significantly decreased(P<0.05),and PSQI score,IL-1βand TNF-αlevels in treatment group were significantly lower than those in control group(P<0.05).During the treatment,the adverse reaction rate in the treatment group(6.67%)was significantly lower than that in the control group(16.67%,P<0.05).Conclusion The combination of Shumian Tablets and Zolpidem Tartrate Tablets can significantly improve the curative effect,effectively improve the sleep quality of patients,and improve the inflammatory response of the body,and it is safe and effective.