皮脂腺在护肤领域的研究进展

Research progress of sebaceous glands in the field of skin care

近年来,寻常痤疮、特应性皮炎等损容性皮肤病的发病率明显增加,其发病机理与皮脂腺功能异常密切相关。皮脂腺存在于真皮层,是皮肤的重要附属器官之一,其上存在着大量受体,受多种机制调控,其功能异常会造成多种皮肤问题。但目前国内对皮肤脂质的研究多针对于细胞间脂质,对皮脂腺分泌的脂质的作用机制研究还不够深入,临床应用与护肤品开发仍需大量基础研究支撑。文章从护肤角度对皮脂腺维持皮肤屏障功能、参与炎症反应、调控衰老进程以及调控肤色方面的作用机制进行了总结,并对皮脂腺相关皮肤问题、皮脂腺功能相关检测方法以及与皮脂腺调控相关的护肤品成分等进行了系统的概述,旨在为皮脂腺功能相关的皮肤护理和皮肤问题解决提供参考依据。

In recent years,the incidence of disfiguring dermatosis such as acne vulgaris and atopic dermatitis has increased significantly,and its pathogenesis is closely related to abnormal sebaceous gland function.Sebaceous glands,located in the dermis,are important skin appendages.There are a large number of receptors on the sebaceous glands,which are regulated by a variety of factors.Abnormity in functions of sebaceous glands may cause a variety of skin problems.However,currently,domestic researchers have mostly paid attention to intercellular lipids,while the effects and mechanism of the sebum are not explored in depth,which causes lack of sufficient theoretical support in clinical application and the development of skin care products.In this paper,the mechanisms by which sebaceous glands maintain skin barrier function,participate in inflammation,and regulate senescence process and skin color from the perspective of skin care are summarized.Skin problems,detection methods and skin care ingredients related to sebaceous glands are systematically reviewed,aiming to provide references for solving relevant problems in skin care.