推拿针刺联合治疗脑梗死后偏瘫对患者神经功能恢复及血清Fibulin-5、NO、S100B表达影响

Effects of Massage Combined with Acupuncture in the Treatment of Hemiplegia after Cerebral Infarction on Recovery of Nerve Function and Expression of Serum Fibulin-5,NO and S100B

目的:探讨推拿针刺联合治疗脑梗死后偏瘫对患者神经功能恢复及血清衰老关键蛋白抗原-5(Fibulin-5)、一氧化氮(NO)、S100B蛋白表达影响。方法:选取2018年12月-2021年12月在中国人民解放军总医院京南医疗区就诊的脑梗死后偏瘫患者116例为研究对象,按照随机数字表法将患者分为观察组(n=59)及对照组(n=57),观察组予以推拿针刺联合治疗,对照组予以单纯推拿疗法。对比两组临床治疗效果、纳维亚卒中量表(SSS评分)、Fugl-Meyer运动功能量表(FMA评分)、Barthel指数(BI)、血清Fibulin-5、NO、S100B水平及生活质量评分(GQOLI-74评分)。结果:治疗15 d后,观察组患者临床总有效率高于对照组(93.22%vs 77.19%)(P<0.05),观察组SSS评分、FMA评分及BI评分均高于对照组(P<0.05),观察组血清Fibulin-5、NO水平均高于对照组,而S100B水平低于对照组(P<0.05),观察组GQOLI-74评分中心理功能、社会功能、躯体功能及物质功能评分均高于对照组(P<0.05)。结论:推拿针刺联合治疗脑梗死后偏瘫患者不仅可提高临床效果,还能改善患者神经功能情况和血清Fibulin-5、NO、S100B水平,提高患者生存质量,临床应用价值高。

Objective:To investigate the effects of massage combined with acupuncture in the treatment of hemiplegia after cerebral infarction on the recovery of nerve function and the expression of Fibulin-5,nitric oxide(NO)and S100B proteins in serum.Method:A total of 116 patients with hemiplegia after cerebral infarction who visited Jingnan Medical District,PLA General Hospital from December 2018 to December 2021 were selected as the research objects,and were divided into observation group(n=59)and control group(n=57)by random number table method.The observation group was treated with massage combined with acupuncture,and the control group was treated with massage alone.The clinical treatment effect,Scandinavian stroke scale(SSS score),Fugl-Meyer motor function scale(FMA score),Barthel index(BI),serum Fibulin-5,NO,S100B levels and quality of life questionnaire(GQOLI-74 score)were compared between two groups.Result:Fifteen days after treatment,the total clinical effective rate of the observation group was higher than the control group(93.22%vs 77.19%)(P<0.05),SSS score,FMA score and BI score in the observation group were higher than those in the control group(P<0.05),the levels of serum Fibulin-5 and NO in the observation group were higher than those in the control group,while the level of S100B was lower than that in the control group(P<0.05),the psychological function,social function,physical function and material function of the observation group were higher than those of the control group in GQOLI-74 score(P<0.05).Conclusion:The combined treatment of massage and acupuncture for hemiplegia patients after cerebral infarction can not only improve the clinical efficacy,but also improve the recovery of nerve function and the level of serum Fibulin-5,NO and S100B,improve the quality of life of patients,and has high clinical application value.