维生素D对急性肾损伤的保护作用研究

The Protective Effect of Vitamin D on Acute Kidney Injury

急性肾损伤(AKI)是一组以肾小球滤过率迅速下降为特征的临床综合征。临床检验标准是血清肌酐和尿素氮的快速升高。AKI是一种常见的急性疾病,尽管临床应用了许多策略,但其发病率和死亡率高,预后差。维生素D不仅是一种钙磷调节激素,还被称为肾保护剂,通过抑制氧化应激、炎症反应、足细胞凋亡及肾纤维化,降低尿蛋白,延缓肾脏进展,保护肾功能。本文探讨维生素D对急性肾损伤的保护作用,为AKI的诊断和治疗提供更多的理论依据。

Acute kidney injury(AKI)is a group of clinical syndromes characterized by rapid decline of glomerular filtration rate.The clinical test standard is the rapid increase of serum creatinine and urea nitrogen.AKI is a common acute disease.Although many strategies have been applied in clinic,its incidence rate and mortality rate are high and its prognosis is poor.Vitamin D is not only a calcium and phosphorus regulatory hormone,but also known as renal protective agent.It can inhibit oxidative stress,inflammatory response,podocyte apoptosis and renal fibrosis,reduce urinary protein,delay renal progression and protect renal function.This paper discusses the protective effect of vitamin D on acute kidney injury,so as to provide more theoretical basis for the diagnosis and treatment of AKI.