百日咳免疫机制及黏膜免疫研究进展

Advance in the immunologic mechanism and mucosal immunity of Bordetella pertussis

百日咳是具有高度传染性的呼吸系统疾病。尽管实施了全民免疫计划,百日咳仍然是一个重要的公共卫生问题。现有的百日咳疫苗控制效果欠佳,需要新的疫苗来预防疾病,同时预防百日咳的感染和传播。研发新型百日咳疫苗,需要深入研究百日咳的发病机制和免疫机制,尤其是保护性免疫机制。随着对保护性免疫机制的进一步了解,黏膜疫苗再次受到重视,并采取了新的方法,如鼻腔免疫、外膜囊泡及减毒活疫苗。该文对百日咳免疫机制及黏膜免疫作一综述,以期对新型百日咳疫苗的研发提供思路。

Pertussis,or whooping cough,is a highly contagious respiratory disease.Despite the implementation of the universal immunization program,pertussis remains a significant public health problem.Existing pertussis vaccines have a poorly controlled effect,and new vaccines are needed to protect against pertussis disease,as well as to prevent infection and transmission of Bordetella pertussis.The development of new pertussis vaccines requires an in-depth study of pertussis′s pathogenesis and immune mechanism,especially the protective immune mechanism.With the further understanding of the protective immune mechanism,the mucosal vaccine has been paid more attention,and new approaches,such as nasal immunization,outer membrane vesicles,and live attenuated vaccine have been adopted.This paper summarizes pertussis′s immune mechanism and mucosal immunity to provide ideas for the research and development of new pertussis vaccines.