氧化磷酸化与脓毒症器官损伤

Oxidative phosphorylation in septic organ injury

脓毒症是宿主感染致病微生物导致的全身炎症反应综合征,治疗不当可进展为严重脓毒症,甚至脓毒症休克,是PICU患儿死亡的主要原因之一。脓毒症的炎性反应对细胞的一系列基础生理功能均造成影响,包括线粒体内的氧化磷酸化。氧化磷酸化通过氧的还原产生三磷酸腺苷形式的高能磷酸键,为细胞供能并生成一系列有功能的副产物。在脓毒症时,线粒体中氧化磷酸化的过程发生了一系列复杂的改变,而这些改变又进一步促进了脓毒性器官损伤的发生。该综述旨在说明脓毒症时氧化磷酸化功能变化与脓毒症各器官损伤之间的联系。

Sepsis is a systemic inflammatory response syndrome caused by pathogenic microorganisms that infect the host.If treated improperly,it can progress to severe sepsis or even septic shock.As such,it′s one of the main reasons for the death of children in PICU.The inflammatory response of sepsis exerts great influence on a series of basic physiological functions of cells,including the oxidative phosphorylation of the mitochondria.Oxidative phosphorylation is a process during which oxygen is reduced to generate high-energy phosphate bonds in the form of adenosine triphosphate(ATP),which supplies energy for cells and produces a series of functional by-products.During sepsis,the process of oxidative phosphorylation in mitochondria undergoes a series of complex alterations,which in turn can further promote the development of septic organ injury.The present review aims to clarify the relationship between changes in oxidative phosphorylation and the impairment of various organs in sepsis.