摘要
Spexin是近年利用生物信息学技术发现的一种新型细胞因子。Spexin是由Ch12orf39编码的一种14个氨基酸的短肽,其序列在脊椎动物进化中保守,并在机体多种器官及组织中广泛表达。Spexin的生理作用正日益受到关注。研究表明,Spexin具有多种生理学效应,其发挥生物学作用的主要配体是galanin受体2型和galanin受体3型。Spexin在能量代谢和稳态、心血管功能、摄食行为等方面具有强大的生物学作用,且在缓解疼痛、减轻抑郁及生殖功能等方面的调节中具有一定的作用。该文对Spexin的发现及其在代谢性疾病及摄食行为等方面的生物学作用作一综述。
Spexin is a new cytokine with a short peptide of 14 amino acids encoded by Ch12orf39,which can be identified by bioinformatics technology.The sequence of Spexin is widely expressed in various organs and is conserved during vertebrate evolution.The physiological effects of Spexin are getting increasing attention in recent years.The studies suggest Spexin plays multiple physiological functions,and the main ligands for biological effects are galanin receptor type 2 and galanin receptor type 3.Spexin palys an important biological role in energy metabolism and homeostasis,cardiovascular function and feeding behavior,and even can affect the regulation of pain and depression relief and reproductive function.This review aims to systemically summarize the Spexin and its related biological functions in metabolic diseases and feeding behavior.
作者
沈勤(综述)
侯森
吕海涛(审校)
Shen Qin;Hou Miao;Lyu Haitao(Department of Cardiology,Soochow University Affiliated Children's Hospital,Suzhou 215003,China)
出处
《国际儿科学杂志》
2022年第6期410-413,共4页
International Journal of Pediatrics
基金
国家自然科学基金(81300692)。
关键词
Spexin
肥胖
糖脂代谢
心血管疾病
摄食行为
Spexin
Obesity
Glucose and lipid metabolism
Cardiovascular diseases
Feeding behavior
