摘要
COVID-19已成为严重的全球公共卫生事件,截至2022年6月25日,全球有超过5.4亿人确诊感染,累计死亡人数超过632万。了解COVID-19患者恢复后是否能获得持久免疫保护力是疫苗制备、疾病防控及判断疫情走向的关键。持久免疫保护力的产生核心是免疫记忆性,即针对新型冠状病毒产生有效免疫记忆。本文将围绕新型冠状病毒感染免疫记忆的生成与维持进行综述。
The COVID-19 pandemic has become a serious global public health threat with more than 540 million infections and 6.32 million cases of death as of 25 June,2022.Understanding whether COVID-19 patients can obtain persistent immune protection after recovery is crucial for vaccine development,disease control and epidemic forecast.The persistent immunity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is mainly derived from the immune memory.Thus,the generation and maintenance of immune memory specifically targeted to the virus were reviewed in this paper.
作者
李一唯
刘歌
赵巍
王浩
Li Yiwei;Liu Ge;Zhao Wei;Wang Hao(School of Basic Medical Sciences,Ningxia Key Laboratory on Prevention and Treatment of Common Infectious Diseases,Ningxia Medical University,Yinchuan 750004,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Ningxia Medical University,Yinchuan 750004,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2022年第7期527-534,共8页
Chinese Journal of Microbiology and Immunology
基金
国家自然科学基金(82160691)
宁夏自然科学基金(2020AAC03002)
宁夏重点研发计划项目(2020BEG03060)
国家级大学生创新创业训练计划项目(202010752001)。
