microRNA/lncRNA调控树突状细胞分化、成熟及功能的研究进展

Progress in microRNA/lncRNA regulating dendritic cell differentiation,maturation and function

树突状细胞(dendritic cell,DC)作为专职的抗原提呈细胞,可以激活初始T细胞,在连接固有免疫和适应性免疫中发挥着重要的桥梁作用。因此,DC分化、成熟及功能的调控机制备受关注。随着高通量测序的快速发展,非编码RNA(non-coding RNA,ncRNA)这一庞大家族逐渐被人们熟知。近年来,越来越多研究报道ncRNA在DC分化、成熟及其功能中发挥着重要的调控作用。本文主要对微小RNA(microRNA,miRNA)及长链非编码RNA(long non-coding RNA,lncRNA)在DC分化、成熟及功能方面的相关调控作用进行综述。

Dendritic cells(DC)as professional antigen-presenting cells can activate naïve T cells and play an important role in bridging innate immunity and acquired immunity.Therefore,the differentiation and maturation of DC and the mechanism in its function regulatory have attracted much attention.With the rapid development of high-throughput sequencing,noncoding RNAs(ncRNAs)have been gradually known.In recent years,increasing studies have reported that ncRNAs play an importantly role in regulating the differentiation and maturation of DC.In this paper,the regulatory effects of microRNAs and long ncRNAs on the differentiation,maturation and function of DC were reviewed.