清肺饮联合阿奇霉素治疗小儿肺炎支原体肺炎(痰热闭肺证)疗效观察

Observation on the effect of Qingfei Yin combined with azithromycin on children with mycoplasma pneumoniae pneumonia(syndrome of phlegm-heat blocking the lung)

目的观察清肺饮联合阿奇霉素对小儿肺炎支原体肺炎(痰热闭肺证)的疗效。方法前瞻性选择102例小儿肺炎支原体肺炎痰热闭肺证患儿,并按随机数字表法划分成西医组、中西医联合组。所有患儿均实施常规对症支持,在此基础上西医组应用阿奇霉素治疗,中西医联合组在对照组基础上加用清肺饮治疗。评定2组治疗14 d后的疗效,统计2组治疗前、治疗14 d后中医证候积分,检测2组治疗前、治疗14 d后肺功能指标水平。结果中西医联合组治疗总有效率明显较西医组高(P<0.05);治疗后2组中医证候积分、血清IL-8、IL-13水平和同组治疗前相比均明显降低(P均<0.05),且中西医联合组治疗后均明显较西医组低(P均<0.05);治疗后2组FVC、PEF和同组治疗前相比均明显增高(P均<0.05),且中西医联合组治疗后均明显较对照组高(P均<0.05)。结论对小儿肺炎支原体肺炎(痰热闭肺证)患儿实施清肺饮联合阿奇霉素治疗的效果较为理想,可明显降低中医证候积分及血清IL-8、IL-13水平,有效改善肺功能。

Objective To observe the curative effect of Qingfei Yin combined with azithromycin on children with mycoplasma pneumoniae pneumonia(syndrome of phlegm-heat blocking the lung).Methods A total of 102 children with mycoplasma pneumoniae pneumonia with the syndrome of phlegm-heat blocking the lung,who were diagnosed and treated in the department of pediatrics of Daxing District Maternal and Child Health Care Hospital from January 2020 to June 2021,were prospectively selected and divided into a western medicine group,a combined Chinese and western medicine group according to the random number table method.All the children received a routine symptomatic support.On that basis,the western medicine group was treated with azithromycin,while the combined Chinese and western medicine group was treated additionally with Qingfei Yin.The curative effect of the two groups was evaluated after 14 days of treatment,the TCM syndrome scores of the two groups were counted before and after 14 days of treatment,and the lung function indexes[forced vital capacity(FVC),peak expiratory flow rate(PEF)]and the levels of serum cytokines[interleukin-8(IL-8),interleukin-13(IL-13)]were detected before and after 14 days of treatment in both groups.Results The total effective rate of the combined Chinese and western medicine group was significantly higher than that of the western medicine group(P<0.05).After treatment,the TCM syndrome scores,the levels of serum IL-8 and IL-13 in the two groups were significantly lower than before treatment(all P<0.05),and the combined Chinese and western medicine group was significantly lower than the western medicine group(all P<0.05).After treatment,the indexes of FVC and PEF in the two groups were significantly higher than before treatment(all P<0.05),and the combined Chinese and western medicine group was significantly higher than the control group(all P<0.05).Conclusion Qingfei Yin combined with azithromycin is more effective in the treatment of children with mycoplasma pneumoniae pneumonia(syndrome of phlegm-heat blocking the lung),which can significantly reduce the TCM syndrome scores and the levels of serum IL-8 and IL-13,and effectively improve the lung function.