小儿豉翘清热颗粒联合阿奇霉素对肺炎支原体肺炎患儿炎症因子水平及症状恢复的影响

Effect of Child Chiqiao Qingre Granules and Azithromycin on Inflammatory Factor Level and Symptom Recovery in Children with Mycoplasma Pneumoniae Pneumonia

目的:分析小儿豉翘清热颗粒联合阿奇霉素对肺炎支原体肺炎患儿炎症因子水平及症状恢复的影响。方法:选取2019年2月-2021年8月上饶市立医院收治的82例肺炎支原体肺炎患儿,按照随机数字表法将患者分为联合组(n=41)和单一组(n=41)。单一组进行阿奇霉素治疗,联合组在单一组的基础上应用小儿豉翘清热颗粒。比较两组疗效、炎症因子[γ干扰素(IFN-γ)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、免疫因子[免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)]、症状恢复时间及不良反应发生情况。结果:联合组总有效率为97.56%,高于单一组的78.05%,差异有统计学意义(P<0.05)。治疗后,联合组IFN-γ、IL-8、TNF-α水平均低于单一组,IgG、IgM、IgA均高于单一组,退热时间、咳嗽消失时间、肺部啰音消失时间、炎症吸收时间均早于单一组,差异均有统计学意义(P<0.05)。联合组不良反应发生率为4.88%,低于单一组的21.95%,差异有统计学意义(P<0.05)。结论:小儿豉翘清热颗粒联合阿奇霉素对肺炎支原体肺炎患儿效果良好,可增强免疫力,改善临床症状,减轻炎症反应,并可降低不良反应发生率。

Objective:To analyze the effect of Child Chiqiao Qingre Granules combined with Azithromycin on inflammatory factors level and symptom recovery in children with mycoplasma pneumonia.Method:A total of 82 children with mycoplasma pneumoniae pneumonia admitted to Shangrao Municipal Hospital from February 2019 to August 2021 were selected,they were divided into combined group(n=41)and single group(n=41)according to random number method.Single group was treated with Azithromycin,and combined group was treated with Child Chiqiao Qingre Granules on the basis of single group.The curative effect,inflammatory factors[interferon-γ(IFN-γ),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],immune factors[immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)],symptom recovery time and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the combined group was 97.56%,which was higher than 78.05%of the single group,the difference was statistically significant(P<0.05).After treatment,the levels of IFN-γ,IL-8 and TNF-αof the combined group were lower than those of the single group,while the levels of IgG,IgM and IgA of the combined group were higher than those of the single group,and the fever relief time,cough disappearance time,lung rales disappearance time and inflammation absorption time of the combined group were earlier than those of the single group,the differences were statistically significant(P<0.05).The incidence of adverse reactions of the combined group was 4.88%,which was lower than 21.95%of the single group,the difference was statistically significant(P<0.05).Conclusion:Child Chiqiao Qingre Granules combined with Azithromycin has a good effect,which can enhance immunity,improve clinical symptoms,reduce inflammatory reactions,and reduce the incidence of adverse reactions.