艾司西酞普兰联合美金刚对阿尔茨海默病患者精神行为症状及认知功能的影响

Effects of Escitalopram Combined with Memantine on Mental and Behavioral Symptoms and Cognitive Function in Patients with Alzheimer’s Disease

目的:探讨艾司西酞普兰联合美金刚治疗阿尔茨海默病(AD)患者的临床效果及对精神行为症状、认知功能的影响。方法:选取2019年6月-2021年6月赣州市第三人民医院收治的86例AD患者,按照随机数字表法分为两组,各43例。对照组口服美金刚治疗,观察组在对照组基础上加用艾司西酞普兰治疗。比较两组临床疗效、精神行为症状、认知功能、血清学指标及不良反应发生情况。结果:观察组总有效率高于对照组,治疗后AD病理行为评分表(BEHAVE-AD)评分、神经精神科问卷(NPI)评分、AD评价量表-认知分析量表(ADAS-cog)评分均低于对照组,简易智能精神状态量表(MMSE)评分高于对照组,差异均有统计学意义(P<0.05)。观察组治疗后超敏C反应蛋白(hs-CRP)、丙二醛(MDA)均低于对照组,超氧化物歧化酶(SOD)高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾司西酞普兰联合美金刚可提高AD治疗效果,减轻精神行为症状,加快认知功能恢复,安全可靠。

Objective:To investigate the clinical effect of Escitalopram combined with Memantine in the treatment of patients with Alzheimer’s disease(AD)and its influence on mental and behavioral symptoms and cognitive function.Method:A total of 86 AD patients admitted to the Third People’s Hospital of Ganzhou City from June 2019 to June 2021 were selected and divided into two groups according to the random number table method,with 43 cases in each group.The control group was treated with oral Memantine,and the observation group was additionally treated with Escitalopram on the basis of the control group.The clinical efficacy,mental and behavioral symptoms,cognitive function,serological indicators and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,after treatment,AD pathological behavioral scale(BEHAVE-AD)score,neuropsychiatric inventory(NPI)score,AD evaluation scale-cognitive analysis scale(ADAS-cog)score were lower than those in the control group,and the score of the mini-mental state scale(MMSE)was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the high-sensitivity C reactive protein(hs-CRP)and malondialdehyde(MDA)in the observation group were lower than those in the control group,and the superoxide dismutase(SOD)in the observation group was higher than that in the control group,with statistical significance(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Escitalopram combined with Memantine can improve the therapeutic effect of AD,reduce mental and behavioral symptoms,and speed up the recovery of cognitive function,which is safe and reliable.