尘肺病动物和细胞模型研究进展

Research progress on animal and cell models of pneumoconiosis

尘肺病是我国发病率最高的职业性肺部疾病,目前尚无有效治疗药物,动物和细胞模型是探讨其发病机制、研制有效药物的基础。本文通过整理近几年尘肺病动物模型制备方法和粉尘诱导的不同细胞模型,分析动物模型中不同制备方法的优缺点、造模时长、病理和重要指标变化,细胞模型中粉尘诱导不同细胞模拟不同的病理生理变化,为尘肺病模型的应用和改进提供依据。

Pneumoconiosis is an occupational lung disease with the highest incidence in China.There is no effective treatment drug at present.Animal and cell models are the basis for exploring its pathogenesis and developing effective drugs.In this paper,we sort out the methods of animal models of pneumoconiosis and the different cell models induced by dust in recent years,by analyzing and summarizing the advantages and disadvantages,modeling time,pathology and changes in important indicators of different preparation methods of animal models,as well as different cell models induced by the dust to simulate different pathological models and pathological stages,to provide basis for the application and improvement of pneumoconiosis model.