阴茎硬结症非手术治疗现状与展望

Current status and prospects of non-surgical management of Peyronie's disease

阴茎硬结症(PD)是遗传易感者阴茎反复的微血管或白膜损伤后愈合紊•乱导致结缔组织形成纤维化斑块的疾病,表现为阴茎畸形、勃起功能障碍和阴茎疼痛。PD发病机制尚不完全清楚,其治疗仍然是一个难题。非手术治疗主要用于PD早期患者,以减轻疼痛,防止疾病进展,包括口服药物治疗、局部治疗、机械治疗等;近年来出现一些新的治疗方法,然而由于缺乏大样本的临床研究,这些治疗方法的价值很难评估。为了更好地指导阴茎硬结症早期治疗,现对阴茎硬结症的非手术治疗现状做一综述。

Peyronie's disease(PD)is considered to be a disease in which the connective tissue forms fibrotic plaques after repeated capillary or albuginea injuries in the penis of genetically susceptible individuals.Manifested as penile erectile deformity,erectile dysfunction and penile pain.Because the pathogenesis is not fully understood,the treatment of PD is still a difficult problem.Non-surgical treatments are mainly used for patients in the early stage of the disease to relieve pain and prevent disease progression,including oral drug treatment,topical treatment,mechanical treatment,etc.In recent years,some new treatment methods have emerged.However,there are little large sample clinical studies accurately evaluating the safety and effectiveness of these treatments.In this review,we provide a overview of the current non-surgical treatments of Peyronie's disease.