LED红黄光治疗面部皮炎的临床疗效观察

Clinical observation of LED red and yellow light in the treatment of facial dermatitis

目的研究LED红黄光在面部皮炎治疗中的临床效果。方法67例面部皮炎患者,依据随机数字表法分为对照组(33例)和观察组(34例)。对照组患者采用烟酰胺片口服联合重组人表皮生长因子凝胶外涂治疗,观察组患者在对照组基础上联合面部LED黄光(λ:590 nm)、红光(λ:630 nm)照射治疗。对比两组患者的治疗效果、皮损严重程度、皮肤检测结果、不良反应发生率及预后复发率。结果观察组总有效率为76.47%,明显高于对照组的51.52%,差异具有统计学意义(P<0.05)。治疗后,观察组瘙痒、疼痛、灼热、干燥感、紧绷感及鳞屑、红斑丘疹、脓疱、毛细血管扩张积分分别为(1.05±0.11)、(1.02±0.13)、(0.98±0.10)、(1.13±0.28)、(1.10±0.27)、(1.02±0.13)、(0.93±0.12)、(0.89±0.10)、(0.88±0.13)分,均明显低于对照组的(1.55±0.16)、(1.49±0.17)、(1.50±0.12)、(1.71±0.34)、(1.68±0.33)、(1.57±0.32)、(1.51±0.41)、(1.49±0.22)、(1.50±0.26)分,差异具有统计学意义(P<0.05)。治疗后,观察组经表皮失水率(TEWL)、皮肤pH值检测异常率分别为11.76%、8.82%,明显低于对照组的45.45%、33.33%,差异具有统计学意义(P<0.05)。两组患者治疗期间均未发生明显不良反应,仅有轻微皮肤干燥反应;观察组预后3个月疾病复发率为11.76%,明显低于对照组的33.33%,差异具有统计学意义(P<0.05)。结论在面部皮炎治疗中予以LED红黄光照射辅助治疗效果显著,可有效改善患者面部症状,促进皮损恢复,且治疗中不良反应少,预后复发率低,安全性高,值得推广应用。

Objective To study the clinical effect of LED red and yellow light in the treatment of facial dermatitis.Methods A total of 67 patients with facial dermatitis were divided into control group(33 cases)and observation group(34 cases)according to the random numerical table.Patients in the control group were treated with oral nicotinamide tablets combined with external application of recombinant human epidermal growth factor gel,and patients in the observation group were treated with facial LED yellow light(λ:590 nm)and red light(λ:630 nm)on the basis of the control group.The therapeutic effect,severity of skin lesions,skin test results,incidence of adverse reactions,and prognosis recurrence rate were compared between the two groups.Results The total effective rate of the observation group was 76.47%,which was significantly higher than 51.52%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of itching,pain,burning,dryness,tightness and scaling,erythematous papules,pustules,and angiotelectasis in the observation group were(1.05±0.11),(1.02±0.13),(0.98±0.10),(1.05±0.11),(1.13±0.28),(1.10±0.27),(1.02±0.13),(0.93±0.12),(0.89±0.10),and(0.88±0.13)points,which were significantly lower than(1.55±0.16),(1.49±0.17),(1.50±0.12),(1.71±0.34),(1.68±0.33),(1.57±0.32),(1.51±0.41),(1.49±0.22)and(1.50±0.26)points in the control group,and differences were statistically significant(P<0.05).After treatment,the abnormal rates of transepidermal water loss(TEWL)and skin pH in the observation group were 11.76%and 8.82%,respectively,which were significantly lower than 45.45%and 33.33%in the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during treatment,only mild skin dryness reaction.The disease recurrence rate in the observation group at 3 months of prognosis was 11.76%,which was significantly lower than 33.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of facial dermatitis,LED red and yellow light irradiation can effectively improve the patient's facial symptoms and promote the recovery of skin lesions,with few adverse reactions,low recurrence rate and high safety,which is worthy of promotion and application.