传统外科手术与ESD治疗早期胃癌的疗效对比

Comparison of efficacy of conventional surgery and ESD in the treatment of early gastric cancer

目的探讨对比早期胃癌患者应用内镜黏膜下剥离术(ESD)与传统外科手术治疗的临床效果。方法86例早期胃癌患者,根据手术方法不同分为对照组(38例)与观察组(48例)。对照组应用传统外科手术治疗,观察组应用ESD进行治疗。对比两组手术指标、并发症发生率、术后生存率。结果观察组手术时间(56.31±11.59)min、住院时间(6.54±2.13)d短于对照组的(80.07±17.16)min、(9.79±2.56)d,术中出血量(62.79±11.37)ml少于对照组的(109.2±12.25)ml,差异有统计学意义(P<0.05)。观察组并发症发生率为6.25%,低于对照组的23.68%,差异有统计学意义(P<0.05)。随访24个月,观察组患者术后1年生存率为100.0%(48/48),2年生存率为97.9%(47/48);对照组者术后1年生存率为100.0%(38/38),2年生存率为97.3%(37/38);两组术后1年生存率、2年生存率对比,差异无统计学意义(P>0.05)。结论早期胃癌患者应用ESD治疗,可缩短住院时间,降低手术损伤,促进患者康复,有效控制病情,对提升患者整体健康水平作用显著,建议临床广泛应用。

Objective To discuss the clinical effect of conventional surgery and endoscopic submucosal dissection(ESD)in the treatment of early gastric cancer.Methods A total of 86 patients with early gastric cancer were divided into control group(38 cases)and observation group(48 cases)according to different surgical methods.The control group was treated with conventional surgery,and the observation group was treated with ESD.The surgical indicators,complication rates,and postoperative survival rates were compared between the two groups.Results In the observation group,the operation time(56.31±11.59)min and hospitalization time(6.54±2.13)d were shorter than(80.07±17.16)min and(9.79±2.56)d in the control group,and less intraoperative blood loss(62.79±11.37)ml than(109.2±12.25)ml in the control group.All the differences were statistically significant(P<0.05).The complication rate in the observation group was 6.25%,which was lower than 23.68%in the control group,and the difference was statistically significant(P<0.05).After 24 months of follow-up,the 1-year survival rate of the observation group was 100.0%(48/48),the 2-year survival rate was 97.9%(47/48);the 1-year survival rate of the control group was 100.0%(38/38),the 2-year survival rate was 97.3%(37/38).There was no statistically significant difference in the 1-year survival rate and 2-year survival rate between the two groups(P>0.05).Conclusion The application of ESD treatment for early gastric cancer patients can shorten the hospitalization time,reduce the surgical damage,promote the recovery of patients,effectively control the disease,and improve the overall health of patients,so it is recommended to be widely used in clinical practice.