恩替卡韦与替诺福韦酯对乙肝肝硬化初诊患者肝功能的影响

Effects of Entecavir and Tenofovir on Liver Function of Newly Diagnosed Patients with Hepatitis B Cirrhosis

目的:比较恩替卡韦(ETV)与替诺福韦酯(TDF)对乙肝肝硬化初诊患者肝功能的影响。方法:选取2018年1月-2020年1月深圳市第三人民医院收治的乙肝肝硬化初诊患者50例为研究对象,采用随机数字表法分为对照组和观察组,各25例,对照组采用ETV治疗,观察组采用TDF治疗。比较两组患者治疗后乙肝病毒的脱氧核糖核酸(HBV-DNA)水平、肝功能指标、肝纤维化指标。结果:治疗后,观察组的HBV-DNA、谷草转氨酶、谷丙转氨酶均低于对照组,差异有统计学意义(P<0.05);观察组Ⅳ型胶原、透明质酸、层粘连蛋白水平均低于对照组,差异有统计学意义(P<0.05)。结论:TDF用于治疗乙型肝炎肝硬化患者可有效抑制乙型肝炎病毒复制,且具有抑制肝纤维化、改善肝功能的作用。

Objective:To explore the effects of entecavir(ETV)and tenofovir(TDF)on liver function of newly diagnosed patients with hepatitis B cirrhosis.Methods:Fifty newly diagnosed patients with hepatitis B cirrhosis who were treated in Shenzhen Third People's Hospital from January 2018 to January 2020 were selected as the study subjects,accordingly to random number table method,they were randomly divided into control group and observation group,with 25 cases in each group.The control group was treated with ETV and the observation group was treated with TDF.The levels of hepatitis B virus deoxyribonucleic acid(HBVDNA),liver function indexes and liver fibrosis indexes were compared between the two groups after treatment.Results:After treatment,the levels of HBV-DNA,aspartate aminotransferase and alanine aminotransferase in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The levels of type IV collagen,hyaluronic acid and laminin in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:TDF can effectively inhibit HBV replication,inhibit liver fibrosis and improve liver function in patients with hepatitis B cirrhosis.