头孢呋辛关键中间体DCCF的制备工艺研究

Study on the Preparation Process of Cefuroxime Key Intermediate DCCF

头孢呋辛关键中间体DCCF的合成研究。工艺以二(三氯甲基)碳酸酯作为酰化剂与呋喃铵盐反应制得侧链,然后与水解后的7-ACA进行缩合反应,采用乙醇进行结晶、过滤、干燥得到目标产物。对合成过程中的摩尔比、反应时间、结晶溶剂、结晶参数进行优化,得到一条新的工艺路线。该工艺路线易操作、收率、纯度高、制备过程环保三废少、成本低,适用于大规模工业化生产。

Synthesis of cefuroxime key intermediate DCCF.The process uses bis(trichloromethyl)carbonate as an acylating agent and reacts with furan ammonium salt to obtain a side chain,which is then subjected to condensation reaction with hydrolyzed 7-ACA,crystallized with ethanol,filtered and dried to obtain the target product.The molar ratio,reaction time,crystallization solvent and crystallization parameters in the synthesis process were optimized,and a new process route was obtained.The process route is easy to operate,the yield and purity are high,the preparation process is environmentally friendly and the three wastes are few,and the cost is low,and is suitable for large-scale industrial production.