中枢多巴胺能系统调节疼痛的研究进展

Research advance on the central dopamine system in the regulation pain

多巴胺能系统的功能失调可通过增强或减弱伤害性信号的转导直接调节痛觉,也可通过作用于情感和认知过程,影响个体对伤害性感觉的预期值、体验和解释,从而间接地调节痛觉。文章综述了中枢多巴胺能系统的功能解剖学构成,并阐述了多巴胺在疼痛中的关键作用,旨在为深入探讨多巴胺在自然镇痛中的作用,并为一系列疼痛症状的治疗提供新思路和方向。

The dopaminergic system dysfunction can directly regulate pain sensation by enhancing or decreasing the transmis⁃sion of nociceptive signals and indirectly regulating pain sensation by affecting the expectation,experience,and interpretation of noci⁃ceptive signals.This paper reviews the functional anatomy of the central dopamine nervous system and elucidates the crucial role of do⁃pamine in pain.This study aims to provide new ideas and directions for treating a series of pain symptoms by exploring the role of dopa⁃mine in natural analgesia.