氢气对脓毒症多器官保护作用机制的研究进展

Research advances in the protective mechanism of hydrogen on multiple organs in sepsis

脓毒症是机体对感染所引起的反应失衡,最终导致危及生命的器官功能障碍的疾病。氢气作为一种气体信号分子,目前发现其对肿瘤、哮喘、慢性阻塞性肺疾病和脓毒症等多种炎性疾病具有治疗作用。文章主要阐述脓毒症造成脑、肺、心脏等器官损伤涉及的多种机制,以及氢气如何通过抗炎、选择性抗氧化、抗细胞凋亡、调节信号通路等发挥辅助治疗作用。总结氢气对脓毒症器官损害的保护机制,将为氢气治疗脓毒症的临床转化提供支持。

Sepsis is a disease in which the body's response to infection is unbalanced and eventually leads to life⁃threatening organ dysfunction.As a signal gas,hydrogen has been found to have therapeutic effects on many inflammatory diseases,such as tumor,asthma,chronic obstructive pulmonary disease and sepsis.This article mainly expounds the various mechanisms involved in brain,lung,heart and other organ damage caused by sepsis,and how hydrogen plays the role of adjunctive therapy on sepsis organ damage through anti⁃inflammatory,selective antioxidant,anti⁃apoptosis and regulating signal pathway.To summarize the protective mechanism of hydrogen on sepsis organ damage and provide support for the clinical transformation of hydrogen in the treatment of sepsis.