MRI影像组学与乳腺癌肿瘤新生血管相关性研究

Correlation between MRI radiomics and neovascularization of breast cancer

乳腺癌是严重危害全球女性健康的恶性肿瘤。乳腺癌的高度异质性导致难以对其进行精准评估,从而不利于其个性化治疗的实践与发展。肿瘤新生血管参与肿瘤异质性的形成,并在乳腺癌治疗反应、预后复发等方面发挥关键作用,如何更好地借助肿瘤新生血管来评估乳腺癌发生发展并推进精准治疗是当前临床亟待解决的问题。乳腺MRI影像组学作为一个新的研究领域,其高通量提取和定量分析的优势不仅能无创提取肿瘤及其新生血管的生物学相关信息,而且能进一步从分子及基因水平实现对肿瘤新生血管相关因子及通路的表征,因此乳腺MRI影像组学在评估肿瘤新生血管中具有极大的潜力。本文从乳腺MRI影像组学与乳腺癌发生发展及其肿瘤新生血管等方面进行阐述,以期为临床精准诊治提供新的思路。

Breast cancer is a malignancy that seriously harms women’s health worldwide. The high heterogeneity of breast cancer makes it difficult to accurately assess it, which is not conducive to the practice and development of its personalized treatment. Tumor angiogenesis is involved in the formation of tumor heterogeneity and plays a key role in breast cancer treatment response, prognosis and recurrence. How to better use tumor angiogenesis to evaluate the occurrence and development of breast cancer and promote precise treatment is an urgent clinical problem to be solved. As a new research field, breast MRI radiomics has the advantages of high-throughput extraction and quantitative analysis, which can not only non-invasively extract biologically relevant information of tumors and their new blood vessels, but also further realize the characterization of tumor angiogenesis-related factors and pathways at the molecular and gene levels. Therefore, breast MRI radiomics has great potential in evaluating tumor angiogenesis. In this paper, the relationship between breast MRI radiomics and the occurrence and development of breast cancer and tumor neovascularization are expounded, in order to provide new ideas for clinical accurate diagnosis and treatment.