嗜酸粒细胞增多表型慢性阻塞性肺疾病的临床研究进展

Clinical research progress of eosinophilic chronic obstructive pulmonary disease

慢性阻塞性肺疾病(慢阻肺)是一种异质性疾病, 因其在临床症状、病理学、影像学、治疗反应、预后等方面的差异, 近年来提出了慢阻肺表型的学说。其中嗜酸粒细胞增多表型在临床特征、治疗反应及预后方面存在特异性, 受到广泛的关注。国内外关于嗜酸粒细胞增多型慢阻肺的临床研究有许多新的进展, 本文将着重对该表型流行病学、临床特征、治疗反应、预后、气道微生态、生物治疗等方面的研究进展进行综述。

Chronic obstructive pulmonary disease(COPD)is a heterogeneous disease,and the concept of COPD phenotype has been proposed in recent years.The eosinophilic phenotype gets widespread attention because of its specificity in clinical characteristics,treatment response,and prognosis.There are many new progresses in clinical studies on this phenotype and we reviewed these study results regarding epidemiology,clinical characteristics,response to treatment,prognosis,airway microbiome,and biotherapy.We hope to help clinicians understand better the clinical features of this phenotype and provide meaningful information for further study,which may contribute to the treatment and prevention of COPD.