摘要
儿童新型冠状病毒感染后综合征(简称新冠后综合征)是指新型冠状病毒感染后出现持续12周以上的躯体症状或症候群,可以表现为各种体征和症状的组合。女童、学龄期及青少年、重症新型冠状病毒感染、特应性体质及身体基础状况较差是患儿发生新冠后综合征的高危因素。其发病机制可能与病毒持续存在、自身免疫、慢性炎症反应、血管内皮细胞炎症和微血栓形成等相关。目前儿童新冠后综合征以缓解症状、康复治疗及心理支持等综合治疗为主。现对儿童新冠后综合征的流行病学、临床表现、发病机制、诊治及管理进行综述,以提高临床医师对该疾病的认识。
Post-COVID-19 condition in children refers to the presence of physical symptoms or syndromes lasting more than 12 weeks after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,which can be manifested as a combination of various signs and symptoms.Girls,school-aged,adolescents,and children with severe illness in the acute phase of COVID-19,with underlying allergic diseases and poor baseline physical and mental health are high-risk factors for post-COVID-19 condition in children.Pathogenesis may be related to viral persistence,autoimmunity,chronic inflammatory responses,chronic inflammation of vascular endothelial cells,and microthrombosis.A comprehensive treatment scheme including symptoms relieving treatment,rehabilitation,and psychological support.This article reviews the epidemiology,clinical manifestations,pathogenesis,diagnosis,treatment,and management of the post-COVID-19 condition in children to improve clinicians′comprehension of the disease.
作者
黄璐
鲍燕敏
郑跃杰
杨永弘
申昆玲
Huang Lu;Bao Yanmin;Zheng Yuejie;Yang Yonghong;Shen Kunling(Department of Respiratory,Shenzhen Children′s Hospital,Shenzhen 518038,China;Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,National Clinical Research Center for Respiratory Disease,National Center for Children′s Health,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2022年第14期1107-1111,共5页
Chinese Journal of Applied Clinical Pediatrics
基金
深圳市医学重点学科建设经费(SZXK032)。
关键词
新型冠状病毒后综合征
新型冠状病毒
儿童
Post-COVID-19 condition
Severe acute respiratory syndrome coronavirus 2
Child
